{"doi":"10.1101/gad.1372505","title":"The <i>Drosophila</i> microRNA iab-4 causes a dominant homeotic transformation of halteres to wings","abstract":"<jats:p>The <jats:italic>Drosophila</jats:italic> Bithorax Complex encodes three well-characterized homeodomain proteins that direct segment identity, as well as several noncoding RNAs of unknown function. Here, we analyze the <jats:italic>iab-4</jats:italic> locus, which produces the microRNAs iab-4-5p and iab-4-3p. <jats:italic>iab-4</jats:italic> is analogous to <jats:italic>miR-196</jats:italic> in vertebrate Hox clusters. Previous studies demonstrate that miR-196 interacts with the Hoxb8 3′ untranslated region. Evidence is presented that miR-iab-4-5p directly inhibits <jats:italic>Ubx</jats:italic> activity in vivo. Ectopic expression of <jats:italic>mir-iab-4-5p</jats:italic> attenuates endogenous Ubx protein accumulation and induces a classical homeotic mutant phenotype: the transformation of halteres into wings. These findings provide the first evidence for a noncoding homeotic gene and raise the possibility that other such genes occur within the Bithorax complex. We also discuss the regulation of <jats:italic>mir-iab-4</jats:italic> expression during development.</jats:p>","journal":"Genes &amp; Development","year":2005,"id":44878,"datarank":6.875019302399872,"base_score":5.093750200806762,"endowment":5.093750200806762,"self_citation_contribution":0.7640625301210144,"citation_network_contribution":6.110956772278858,"self_endowment_contribution":0.7640625301210144,"citer_contribution":6.110956772278858,"corpus_percentile":null,"corpus_rank":null,"citation_count":162,"citer_count":147,"citers_with_citation_signal":138,"citers_with_endowment":138,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":210502,"name":"Frédéric Biemar","orcid":null,"position":1,"is_corresponding":false},{"id":210503,"name":"Jessica Piel","orcid":null,"position":2,"is_corresponding":false},{"id":210504,"name":"Mike Levine","orcid":null,"position":3,"is_corresponding":false},{"id":210505,"name":"Eric C. 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