{"doi":"10.1101/gad.12.14.2114","title":"TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300","abstract":"<jats:p>TGF-β and activin induce the phosphorylation and activation of Smad2 and Smad3, but how these proteins stimulate gene transcription is poorly understood. We report that TGF-β receptor phosphorylation of Smad3 promotes its interaction with the paralogous coactivators CBP and p300, whereas CBP/p300 binding to nonphosphorylated Smad3 or its oligomerization partner Smad4 is negatively regulated by Smad–intramolecular interactions. Furthermore, p300 and TGF-β receptor-phosphorylated Smad3 synergistically augment transcriptional activation. Thus, CBP/p300 are important components of activin/TGF-β signaling and may mediate the antioncogenic functions of Smad2 and Smad4.</jats:p>","journal":"Genes &amp; Development","year":1998,"id":37791,"datarank":14.351394169411636,"base_score":6.2324480165505225,"endowment":6.2324480165505225,"self_citation_contribution":0.9348672024825785,"citation_network_contribution":13.416526966929057,"self_endowment_contribution":0.9348672024825785,"citer_contribution":13.416526966929057,"corpus_percentile":null,"corpus_rank":null,"citation_count":508,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":188680,"name":"Nicholas J. 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