{"doi":"10.1101/gad.12.12.1775","title":"Proteasomal regulation of nuclear receptor corepressor-mediated repression","abstract":"<jats:p>Repression of gene transcription is a fundamental property of nuclear hormone receptors. We report here that cell-specific repression by nuclear receptors correlates with levels of nuclear receptor corepressor (N-CoR) protein. N-CoR protein levels are regulated by mSiah2, a mammalian homolog of <jats:italic>Drosophila Seven in absentia</jats:italic>that targets N-CoR for proteasomal degradation. mSiah2 expression is cell-type specific and differentially regulates the repressive activities of nuclear receptors. These findings establish targeted proteolysis of transcriptional coregulators as a mechanism for cell-specific regulation of gene transcription.</jats:p>","journal":"Genes &amp; Development","year":1998,"id":22655,"datarank":12.319210488819204,"base_score":5.4116460518550396,"endowment":5.4116460518550396,"self_citation_contribution":0.8117469077782561,"citation_network_contribution":11.507463581040948,"self_endowment_contribution":0.8117469077782561,"citer_contribution":11.507463581040948,"corpus_percentile":null,"corpus_rank":null,"citation_count":223,"citer_count":200,"citers_with_citation_signal":188,"citers_with_endowment":188,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":58687,"name":"Matthew G. Guenther","orcid":"0009-0006-6779-1195","position":1,"is_corresponding":false},{"id":141706,"name":"Richard W. Carthew","orcid":null,"position":2,"is_corresponding":false},{"id":39746,"name":"Mitchell A. 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