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Addition of Met–tRNA<jats:sub>i</jats:sub><jats:sup>Met</jats:sup>, eIF2, and GTP to these binary ribosomal complexes resulted in formation of 48S preinitiation complexes. The striking similarities between this eukaryotic initiation mechanism and the mechanism of translation initiation in prokaryotes are discussed.</jats:p>","journal":"Genes &amp; Development","year":1998,"id":21019,"datarank":15.3062849852517,"base_score":6.583409222158765,"endowment":6.583409222158765,"self_citation_contribution":0.9875113833238148,"citation_network_contribution":14.318773601927886,"self_endowment_contribution":0.9875113833238148,"citer_contribution":14.318773601927886,"corpus_percentile":null,"corpus_rank":null,"citation_count":722,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":136907,"name":"Ivan N. 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Pestova","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":6.583409222158765,"endowment":6.583409222158765,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9420332","pmcid":"PMC316404","openalex_id":"https://openalex.org/W2104947461","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"","title":null},{"funder_name":"Wellcome Trust","grant_id":"","title":null}],"total_grants":2,"fwci":null,"citation_percentile":null,"influential_citations":39,"citation_trend":[{"year":2012,"count":27},{"year":2013,"count":25},{"year":2014,"count":23},{"year":2015,"count":31},{"year":2016,"count":15},{"year":2017,"count":20},{"year":2018,"count":24},{"year":2019,"count":14},{"year":2020,"count":15},{"year":2021,"count":8},{"year":2022,"count":8},{"year":2023,"count":9},{"year":2024,"count":7},{"year":2025,"count":15},{"year":2026,"count":5}],"oa_status":"gold","license":null,"oa_locations":[{"url":"http://genesdev.cshlp.org/content/12/1/67.full.pdf","host_type":"journal"},{"url":"http://genesdev.cshlp.org/content/12/1/67.full.pdf","host_type":"GOLD"},{"url":"http://genesdev.cshlp.org/content/12/1/67.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1101/gad.12.1.67","host_type":"publisher"},{"url":"https://doi.org/10.1101/gad.12.1.67","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9420332","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/316404","host_type":"repository"}],"fields_of_study":["Viral Infections and Immunology Research","Animal Disease Management and Epidemiology","RNA and protein synthesis mechanisms","Biology","Medicine","Animals","Base Sequence","Classical Swine Fever Virus","Codon, Initiator","Cytoplasm","DNA Primers","Eukaryotic Cells","Eukaryotic Initiation Factor-2","Eukaryotic Initiation Factor-3","Eukaryotic Initiation Factor-4A","Eukaryotic Initiation Factor-4F","Eukaryotic Initiation Factors","Hepacivirus","Humans","Molecular Sequence Data","Nucleic Acid Conformation","Peptide Chain Initiation, Translational","Peptide Initiation Factors","Prokaryotic Cells","Protein Biosynthesis","RNA, Transfer, Met","RNA, Viral","Rabbits","Ribosomal Protein S9","Ribosomal Proteins","Ribosomes","Structure-Activity Relationship"],"mesh_terms":["Ribosomal Protein S9","Animals","Base Sequence","Cytoplasm","Eukaryotic Cells","Classical Swine Fever Virus","Humans","Molecular Sequence Data","Nucleic Acid Conformation","Peptide Chain Initiation, Translational","Peptide Initiation Factors","Prokaryotic Cells","Rabbits","Ribosomal Proteins","Ribosomes","RNA, Transfer, Met","RNA, Viral","Structure-Activity Relationship","Protein Biosynthesis","Eukaryotic Initiation Factor-2","Hepacivirus","DNA Primers","Codon, Initiator","Eukaryotic Initiation Factor-4F","Eukaryotic Initiation Factor-4A","Eukaryotic Initiation Factor-3","Eukaryotic Initiation Factors","Classical swine fever virus"],"keywords":["Internal ribosome entry site","Biology","Eukaryotic initiation factor","Initiation factor","Eukaryotic translation","Eukaryotic Small Ribosomal Subunit","Start codon","Ribosomal RNA","Eukaryotic Ribosome","5.8S ribosomal RNA","EIF4G","EIF4E","Transcription preinitiation complex","Cell biology","Genetics","Translation (biology)","Ribosome","RNA","Messenger RNA","Gene","Gene expression"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.24112979.v1","title":"Additional file 1 of Development of short hairpin RNA expression vectors targeting the internal ribosomal entry site of the classical swine fever virus genomic RNA","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.24112979","title":"Additional file 1 of Development of short hairpin RNA expression vectors targeting the internal ribosomal entry site of the classical swine fever virus genomic RNA","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-06T14:05:55.670119Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}