{"doi":"10.1101/gad.1011602","title":"Synapsis-dependent and -independent mechanisms stabilize homolog pairing during meiotic prophase in\n                    <i>C. elegans</i>","abstract":"<jats:p>\n                    Analysis of\n                    <jats:italic>Caenorhabditis elegans syp-1</jats:italic>\n                    mutants reveals that both synapsis-dependent and -independent mechanisms contribute to stable, productive alignment of homologous chromosomes during meiotic prophase. Early prophase nuclei undergo normal reorganization in\n                    <jats:italic>syp-1</jats:italic>\n                    mutants, and chromosomes initially pair. However, the polarized nuclear organization characteristic of early prophase persists for a prolonged period, and homologs dissociate prematurely; furthermore, the synaptonemal complex (SC) is absent. The predicted structure of SYP-1, its localization at the interface between intimately paired, lengthwise-aligned pachytene homologs, and its kinetics of localization with chromosomes indicate that SYP-1 is an SC structural component. A severe reduction in crossing over together with evidence for accumulated recombination intermediates in\n                    <jats:italic>syp-1</jats:italic>\n                    mutants indicate that initial pairing is not sufficient for completion of exchange and implicates the SC in promoting crossover recombination. Persistence of polarized nuclear organization in\n                    <jats:italic>syp-1</jats:italic>\n                    mutants suggests that SC polymerization may provide a motive force or signal that drives redispersal of chromosomes. Whereas our analysis suggests that the SC is required to stabilize pairing along the entire lengths of chromosomes, striking differences in peak pairing levels for opposite ends of chromosomes in\n                    <jats:italic>syp-1</jats:italic>\n                    mutants reveal the existence of an additional mechanism that can promote local stabilization of pairing, independent of synapsis.\n                  </jats:p>","journal":"Genes &amp; Development","year":2002,"id":589752,"datarank":13.154718360962661,"base_score":6.018593214496234,"endowment":6.018593214496234,"self_citation_contribution":0.9027889821744353,"citation_network_contribution":12.251929378788226,"self_endowment_contribution":0.9027889821744353,"citer_contribution":12.251929378788226,"corpus_percentile":null,"corpus_rank":null,"citation_count":410,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":203611,"name":"Mónica P. Colaiácovo","orcid":null,"position":1,"is_corresponding":false},{"id":1178137,"name":"Kent McDonald","orcid":null,"position":2,"is_corresponding":false},{"id":202925,"name":"Anne M. Villeneuve","orcid":null,"position":3,"is_corresponding":false},{"id":783844,"name":"Amy J. MacQueen","orcid":"0000-0002-0919-7538","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Synapsis-dependent and -independent mechanisms stabilize homolog pairing during meiotic prophase in\n                    <i>C. elegans</i>","abstract":"<jats:p>\n                    Analysis of\n                    <jats:italic>Caenorhabditis elegans syp-1</jats:italic>\n                    mutants reveals that both synapsis-dependent and -independent mechanisms contribute to stable, productive alignment of homologous chromosomes during meiotic prophase. Early prophase nuclei undergo normal reorganization in\n                    <jats:italic>syp-1</jats:italic>\n                    mutants, and chromosomes initially pair. However, the polarized nuclear organization characteristic of early prophase persists for a prolonged period, and homologs dissociate prematurely; furthermore, the synaptonemal complex (SC) is absent. The predicted structure of SYP-1, its localization at the interface between intimately paired, lengthwise-aligned pachytene homologs, and its kinetics of localization with chromosomes indicate that SYP-1 is an SC structural component. A severe reduction in crossing over together with evidence for accumulated recombination intermediates in\n                    <jats:italic>syp-1</jats:italic>\n                    mutants indicate that initial pairing is not sufficient for completion of exchange and implicates the SC in promoting crossover recombination. Persistence of polarized nuclear organization in\n                    <jats:italic>syp-1</jats:italic>\n                    mutants suggests that SC polymerization may provide a motive force or signal that drives redispersal of chromosomes. Whereas our analysis suggests that the SC is required to stabilize pairing along the entire lengths of chromosomes, striking differences in peak pairing levels for opposite ends of chromosomes in\n                    <jats:italic>syp-1</jats:italic>\n                    mutants reveal the existence of an additional mechanism that can promote local stabilization of pairing, independent of synapsis.\n                  </jats:p>","is_dataset_classified":null,"base_score":6.018593214496234,"endowment":6.018593214496234,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12231631","pmcid":"PMC187442","openalex_id":"https://openalex.org/W2147125910","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM053804","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01GM53804","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"F32HD41329","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"F32 HD041329","title":null}],"total_grants":4,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2012,"count":14},{"year":2013,"count":18},{"year":2014,"count":18},{"year":2015,"count":14},{"year":2016,"count":21},{"year":2017,"count":18},{"year":2018,"count":16},{"year":2019,"count":18},{"year":2020,"count":27},{"year":2021,"count":25},{"year":2022,"count":19},{"year":2023,"count":18},{"year":2024,"count":17},{"year":2025,"count":19},{"year":2026,"count":11}],"oa_status":"gold","license":null,"oa_locations":[{"url":"http://genesdev.cshlp.org/content/16/18/2428.full.pdf","host_type":"journal"},{"url":"http://genesdev.cshlp.org/content/16/18/2428.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1101/gad.1011602","host_type":"publisher"},{"url":"https://doi.org/10.1101/gad.1011602","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12231631","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/187442","host_type":"repository"}],"fields_of_study":["Genetics, Aging, and Longevity in Model Organisms","DNA Repair Mechanisms","Mitochondrial Function and Pathology","Animals","Caenorhabditis elegans","Caenorhabditis elegans Proteins","Chromosome Pairing","Endodeoxyribonucleases","Esterases","Female","Genes, Helminth","Helminth Proteins","Male","Meiosis","Microscopy, Electron","Mutation","Prophase","Synaptonemal Complex","Meiotic Recombination Protein SPO11"],"mesh_terms":["Meiotic Recombination Protein SPO11","Animals","Endodeoxyribonucleases","Esterases","Female","Male","Meiosis","Microscopy, Electron","Mutation","Prophase","Synaptonemal Complex","Helminth Proteins","Caenorhabditis elegans","Genes, Helminth","Chromosome Pairing","Caenorhabditis elegans Proteins"],"keywords":["Synapsis","Synaptonemal complex","Biology","Prophase","Homologous chromosome","Meiosis","Chromosomal crossover","Pairing","Genetics","Cell biology","Caenorhabditis elegans","Mutant","Gene","Physics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-24T06:07:04.041659Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}