{"doi":"10.1101/cshperspect.a041549","title":"Diet and Cancer Metabolism","abstract":"Diet and exercise are modifiable lifestyle factors known to have a major influence on metabolism.Clinical practice addresses diseases of altered metabolism such as diabetes or hypertension by altering these factors.Despite enormous public interest, there are limited defined diet and exercise regimens for cancer patients.Nevertheless, the molecular basis of cancer has converged over the past 15 years on an essential role for altered metabolism in cancer.However, our understanding of the molecular mechanisms that underlie the impact of diet and exercise on cancer metabolism is in its very early stages.In this work, we propose conceptual frameworks for understanding the consequences of diet and exercise on cancer cell metabolism and tumor biology and also highlight recent developments.By advancing our mechanistic understanding, we also discuss actionable ways that such interventions could eventually reach the mainstay of both medical oncology and cancer control and prevention.N ature and nurture are important in shaping the status of a biological system. 4Both the genetic makeup and the environment that interacts with the living system are highly relevant to all complex diseases and health statuses.For metabolism-broadly defined as the collection of chemical reactions that sustain life-hereditary factors provide the genetic foundation for metabolism, while the environment can modulate the transcription programs, signaling pathways, and chromatin modifying enzymes that regulate metabolic enzymes.Cancer biology has benefit from the enormous advances in technology over the past 50 years.These advancements have played a crucial role in elucidating the essential genetic characteristics of cancer cells (Ding et al. 2018).For instance, the identification of mutations in oncogenes and tumor suppressor genes has provided valuable insights into the development of tumors, progression of metastasis, and the varying susceptibility to certain therapies.Some of the most common cancer genes, including KRAS, PIK3CA, CMYC, and TP53, have substantial im-4 This is an update to a previous article published in Cancer Discovery [Locasale JW (2022).Diet and exercise in cancer metabolism.","journal":"Cold Spring Harbor Perspectives in Medicine","year":2024,"id":484341,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9574,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":366858,"name":"Marcus D. Goncalves","orcid":"0000-0002-0784-9248","position":1,"is_corresponding":false},{"id":256538,"name":"Maira Di Tano","orcid":"0000-0003-1849-9404","position":2,"is_corresponding":false},{"id":1326020,"name":"Guillermo Burgos-Barragan","orcid":"0000-0001-8736-3565","position":3,"is_corresponding":false},{"id":88693,"name":"Jason W. Locasale","orcid":"0000-0002-7766-3502","position":0,"is_corresponding":true}],"reference_count":100,"raw_metadata":null,"created_at":"2026-07-19T02:07:38.055693Z","pmid":"38621831","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}