{"doi":"10.1101/cshperspect.a028720","title":"Systems Chronobiology: Global Analysis of Gene Regulation in a 24-Hour Periodic World","abstract":null,"journal":"Cold Spring Harbor Perspectives in Biology","year":2017,"id":624767,"datarank":0.5806801516361837,"base_score":3.8712010109078907,"endowment":3.8712010109078907,"self_citation_contribution":0.5806801516361837,"citation_network_contribution":0.0,"self_endowment_contribution":0.5806801516361837,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":47,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1615173,"name":"Jake Yeung","orcid":null,"position":1,"is_corresponding":false},{"id":1615174,"name":"Felix Naef","orcid":null,"position":2,"is_corresponding":false},{"id":1368262,"name":"Jérôme Mermet","orcid":"0000-0001-8623-7380","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Systems Chronobiology: Global Analysis of Gene Regulation in a 24-Hour Periodic World","abstract":"Mammals have evolved an internal timing system, the circadian clock, which synchronizes physiology and behavior to the daily light and dark cycles of the Earth. The master clock, located in the suprachiasmatic nucleus (SCN) of the brain, takes fluctuating light input from the retina and synchronizes other tissues to the same internal rhythm. The molecular clocks that drive these circadian rhythms are ticking in nearly all cells in the body. Efforts in systems chronobiology are now being directed at understanding, on a comprehensive scale, how the circadian clock controls different layers of gene regulation to provide robust timing cues at the cellular and tissue level. In this review, we introduce some basic concepts underlying periodicity of gene regulation, and then highlight recent genome-wide investigations on the propagation of rhythms across multiple regulatory layers in mammals, all the way from chromatin conformation to protein accumulation.","is_dataset_classified":null,"base_score":3.8712010109078907,"endowment":3.8712010109078907,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27920039","pmcid":"PMC5334255","openalex_id":"https://openalex.org/W2560563727","authors":[],"funders":[{"funder_name":"European Research Council","grant_id":"260667","title":"Dynamic protein-DNA interactomes and circadian transcription regulatory networks in mammals"},{"funder_name":"Swiss National Science Foundation","grant_id":"153340","title":"Circadian gene regulatory networks in mammals and their impact on cellular functions"},{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"unidentified","title":"unidentified"}],"total_grants":3,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2017,"count":5},{"year":2018,"count":4},{"year":2019,"count":6},{"year":2020,"count":11},{"year":2021,"count":7},{"year":2022,"count":5},{"year":2023,"count":4},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"bronze","license":"cc-by-nc-nd","oa_locations":[{"url":"http://cshperspectives.cshlp.org/content/9/3/a028720.full.pdf","host_type":"journal"},{"url":"http://cshperspectives.cshlp.org/content/9/3/a028720.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1101/cshperspect.a028720","host_type":"publisher"},{"url":"https://doi.org/10.1101/cshperspect.a028720","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27920039","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5334255","host_type":"repository"},{"url":"http://infoscience.epfl.ch/record/227750","host_type":"repository"},{"url":"http://infoscience.epfl.ch/record/227813","host_type":"repository"},{"url":"https://dx.doi.org/10.1101/cshperspect.a028720","host_type":""},{"url":"https://sonar.ch/global/documents/99503","host_type":""},{"url":"https://hdl.handle.net/20.500.14299/136908","host_type":""},{"url":"http://dx.doi.org/10.1101/cshperspect.a028720","host_type":""}],"fields_of_study":["Circadian rhythm and melatonin","Light effects on plants","Photoreceptor and optogenetics research","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Circadian Rhythm","Gene Expression Regulation","Humans","RNA Processing, Post-Transcriptional"],"mesh_terms":["Animals","Circadian Rhythm","Gene Expression Regulation","Humans","RNA Processing, Post-Transcriptional"],"keywords":["Biology","Circadian rhythm","Suprachiasmatic nucleus","Chronobiology","Bacterial circadian rhythms","Oscillating gene","Light effects on circadian rhythm","Neuroscience","Circadian clock","Biological clock","CLOCK","Rhythm","Chromatin","Evolutionary biology","Gene","Genetics","Internal medicine","Gene Expression Regulation","Animals","Humans","RNA Processing, Post-Transcriptional"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T04:49:11.560444Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}