{"doi":"10.1101/286773","title":"The Claustrum Coordinates Cortical Slow-Wave Activity","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>\n                  During sleep and awake rest, the neocortex generates large-scale slow-wave activity. Here we report that the claustrum, a poorly understood subcortical neural structure, coordinates neocortical slow-wave generation. We established a transgenic mouse line allowing genetic and electrophysiological interrogation of a subpopulation of claustral glutamatergic neurons. These claustral excitatory neurons received inputs from glutamatergic neurons in a large neocortical network. Optogenetic activation of claustral neurons\n                  <jats:italic>in vitro</jats:italic>\n                  induced excitatory post-synaptic responses in most neocortical neurons, but elicited action potentials primarily in inhibitory interneurons. Optogenetic activation of claustral neurons\n                  <jats:italic>in vivo</jats:italic>\n                  induced a Down-state featuring a prolonged silencing of neural acticity in all layers of many cortical areas, followed by a globally synchronized Down-to-Up state transition. These results demonstrate a crucial role of the claustrum in synchronizing inhibitory interneurons across the neocortex for spatiotemporal coordination of brain state. Thus, the claustrum is a major subcortical hub for the synchronization of neocortical slow-wave activity.\n                </jats:p>","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":null,"id":34028,"datarank":1.098079913712267,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.6213718391600751,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.6213718391600751,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":23,"citers_with_citation_signal":17,"citers_with_endowment":17,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":176908,"name":"Rumiko Mizuguchi","orcid":null,"position":1,"is_corresponding":false},{"id":176909,"name":"Ayako Ajima","orcid":null,"position":2,"is_corresponding":false},{"id":176910,"name":"Sachiko Mitsui","orcid":null,"position":3,"is_corresponding":false},{"id":176911,"name":"Momoko Shiozaki","orcid":null,"position":4,"is_corresponding":false},{"id":176912,"name":"Hiroki Hamanaka","orcid":null,"position":5,"is_corresponding":false},{"id":176913,"name":"Joshua P. Johansen","orcid":null,"position":6,"is_corresponding":false},{"id":176914,"name":"Kensaku Mori","orcid":null,"position":7,"is_corresponding":false},{"id":176915,"name":"Yoshihiro Yoshihara","orcid":null,"position":8,"is_corresponding":false},{"id":176907,"name":"Kimiya Narikiyo","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24523987","pmcid":null,"openalex_id":"https://openalex.org/W2789435539","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":7},{"year":2021,"count":2},{"year":2022,"count":6},{"year":2023,"count":2},{"year":2024,"count":2},{"year":2025,"count":1}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.biorxiv.org/content/biorxiv/early/2018/03/22/286773.full.pdf","host_type":"repository"},{"url":"https://www.biorxiv.org/content/biorxiv/early/2018/03/22/286773.full.pdf","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.1101/286773","host_type":"publisher"},{"url":"https://doi.org/10.1101/286773","host_type":"repository"}],"fields_of_study":["Sleep and Wakefulness Research","Neural dynamics and brain function","Memory and Neural Mechanisms"],"mesh_terms":[],"keywords":["Claustrum","Neuroscience","Optogenetics","Neocortex","Inhibitory postsynaptic potential","Excitatory postsynaptic potential","Glutamatergic","Biology","Glutamate receptor"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T17:28:02.361880Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}