{"doi":"10.1101/2025.11.25.690462","title":"Zoliflodacin and gepotidacin cross-resistance in <i>Neisseria gonorrhoeae</i>","abstract":"Abstract Resistance to zoliflodacin, a first-in-class antibiotic for gonorrhea treatment, can occur through gyrB D429N , but this mutation’s impact on fitness and resistance to other topoisomerase targeting drugs, including gepotidacin, have been unclear. Here, we show that gyrB D429N confers cross-resistance to gepotidacin in some clinical isolates and that its fitness effect varies with strain back-ground. These findings inform strategies for introducing the new topoisomerase inhibitors into clinical use and for surveillance of resistance.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":555301,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9478,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1453607,"name":"Susanne Blomqvist","orcid":"0000-0002-8967-3564","position":1,"is_corresponding":false},{"id":1278918,"name":"David Helekal","orcid":"0000-0002-9319-7097","position":2,"is_corresponding":false},{"id":904244,"name":"Apabrita Ayan Das","orcid":"0000-0002-1992-003X","position":3,"is_corresponding":false},{"id":329669,"name":"Samantha G. Palace","orcid":"0000-0002-7849-8078","position":4,"is_corresponding":false},{"id":41032,"name":"Yonatan H. Grad","orcid":"0000-0001-5646-1314","position":5,"is_corresponding":false},{"id":1119040,"name":"Aditi Mukherjee","orcid":"0000-0002-2208-9945","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T02:54:59.329539Z","pmid":"41394753","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}