{"doi":"10.1101/2025.11.20.689412","title":"OSM-11 modulates salinity-stress tolerance in <i>Caenorhabditis elegans</i>","abstract":"Abstract Most terrestrial animals exhibit narrow salinity tolerance compared to their marine counterparts. Previous studies identified osm-11 (which encodes a Notch co-ligand) mutations as a driver of hyper-saline tolerance in Caenorhabditis elegans , but mechanistic insights remained unclear. This study employs RNA sequencing and CRISPR/Cas-9 genome editing to demonstrate that osm-11 mutations enhance salinity stress resistance through up-regulation of fatty acid metabolism ( acdh-12 , acs-17 ) and cytochrome P450 pathways ( ugt-15 ), while suppressing calcium signaling. Furthermore, we demonstrated that acdh-12 mutation impairs salinity-stress tolerance by activating ferroptosis and mitophagy, accompanied by down-regulated oxidative phosphorylation and up-regulated autophagic pathways. Morphological observations show that mitochondrial fragmentation contributes to wild-type nematode mortality under high salinity, while enlarged lipid droplets in wild-types correlate with reduced β-oxidation gene expression ( dhs-28 , daf-22 ), whose knockout disrupts tolerance in mutants. These findings unravel the multi-pathway regulatory network of osm-11 -mediated salinity tolerance, providing mechanistic insights for developing protective strategies against environmental salinity stressors impacting animal survival.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":581985,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9516,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":555648,"name":"Beining Xue","orcid":"0000-0001-5531-5737","position":1,"is_corresponding":false},{"id":474652,"name":"Yusu Xie","orcid":"0000-0002-7408-5110","position":2,"is_corresponding":false},{"id":1493856,"name":"Kunlin Li","orcid":null,"position":3,"is_corresponding":false},{"id":475913,"name":"Hanwen Yang","orcid":null,"position":4,"is_corresponding":false},{"id":1493857,"name":"Peiqi Sun","orcid":null,"position":5,"is_corresponding":false},{"id":371987,"name":"Liusuo Zhang","orcid":"0000-0001-5280-181X","position":6,"is_corresponding":false},{"id":475914,"name":"Pengchi Zhang","orcid":null,"position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-19T02:58:51.328454Z","pmid":"41332531","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}