{"doi":"10.1101/2025.10.31.685962","title":"Absence of cortical reorganization following an internal capsule stroke in rodents","abstract":"Stroke is a leading cause of disability, causing chronic motor impairments in many survivors. Although recovery is correlated with cortical reorganization, the impact of lesion location on post-stroke reorganization is uncertain. We compared movement-related neural activity following experimental infarcts to the motor cortex (M1) or internal capsule in rats. Neural activity was recorded from motor and somatosensory regions during a skilled pellet retrieval task longitudinally during the course of recovery. Cortical lesions resulted in early behavioral recovery accompanied by widespread reductions in neural activity across ipsilesional regions, indicative of large-scale reorganization. In contrast, internal capsule lesions produced delayed recovery with no evidence of long-term ipsilesional cortical reorganization. These findings challenge the relevance of cortical reorganization for recovery from subcortical lesions and indicate that post-stroke recovery mechanisms are lesion-specific and that models targeting subcortical white matter are essential for maximizing translational relevance.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":579869,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9564,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":432322,"name":"David J. Guggenmos","orcid":"0000-0002-6753-9049","position":1,"is_corresponding":false},{"id":1490378,"name":"Siddharth S. Sivakumar","orcid":"0000-0002-8621-5867","position":2,"is_corresponding":false},{"id":432320,"name":"Maxwell D. Murphy","orcid":"0000-0002-8559-2361","position":3,"is_corresponding":false},{"id":1490759,"name":"H. Scott Barbay","orcid":null,"position":4,"is_corresponding":false},{"id":381311,"name":"Randolph J. Nudo","orcid":"0000-0002-4674-0907","position":5,"is_corresponding":false},{"id":432321,"name":"David T. Bundy","orcid":"0000-0001-6491-044X","position":6,"is_corresponding":false},{"id":1490758,"name":"Patrick E. Cettina","orcid":null,"position":0,"is_corresponding":true}],"reference_count":84,"raw_metadata":null,"created_at":"2026-07-19T02:58:34.718602Z","pmid":"41280021","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}