{"doi":"10.1101/2025.10.17.683040","title":"Leukemia Risk Factor ARID5B Coordinates HDAC-Mediated Transcriptional Repression","abstract":"Multiple genetic association studies linked variants at ARID5B with predisposition to B-cell derived acute lymphoblastic leukemia (B-ALL) in children. Still, the molecular function of ARID5B remains largely uncharacterized. Here, we employ a combination of proteomics, genomics and transcriptomics to describe the molecular mechanisms of ARID5B. We identify that ARID5B interacts with MIER1, C16ORF87, HDAC1 and HDAC2 forming a chromatin repressor complex. By CUT&RUN, we mapped ARID5B binding in active regions of the genome, tethering HDAC1 and HDAC2 to distal regulatory elements and promoters. Genes actively repressed by the ARID5B repressor complex are involved in B cell proliferation and B cell-specific signaling. Together, we describe how ARID5B assembles into a repressor complex and regulates B cell-specific processes. Understanding its molecular mechanism will help elucidating how non-coding germline variants at ARID5B predispose to B-ALL.","journal":null,"year":2025,"id":1376,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0436,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-10-17","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":16784,"name":"Fabian Frommelt","orcid":"0000-0003-3666-8005","position":1,"is_corresponding":false},{"id":16785,"name":"Brianda L. Santini","orcid":"0000-0001-7539-8680","position":2,"is_corresponding":false},{"id":16786,"name":"Sophie Muller","orcid":null,"position":3,"is_corresponding":false},{"id":16787,"name":"Paul Batty","orcid":"0000-0002-9807-5099","position":4,"is_corresponding":false},{"id":16788,"name":"Gerlinde Karbon","orcid":"0000-0002-6149-3342","position":5,"is_corresponding":false},{"id":16789,"name":"Giulio Superti-Furga","orcid":null,"position":6,"is_corresponding":false},{"id":16790,"name":"Davide Seruggia","orcid":"0000-0001-5014-0499","position":7,"is_corresponding":false},{"id":16791,"name":"Simon Müller","orcid":"0000-0002-5429-0088","position":8,"is_corresponding":false},{"id":16783,"name":"Ana P. Kutschat","orcid":"0000-0002-6360-873X","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}