{"doi":"10.1101/2025.10.10.681620","title":"Characterization of Gait Kinematics and Muscle Function in Becker Muscular Dystrophy Pigs: a pilot study","abstract":"Vertebrate animal models of Becker muscular dystrophy (BMD) have been developed. Here, we characterized the gait kinematics and muscle function of a naturally occurring BMD pig model of dystrophin insufficiency. BMD pigs tended to have alterations in hip range of motion (ROM): hip (67%, 95% CI -0.64 to 14.12 degrees). While parameters were unaltered in extensor muscles, the dystrophin levels in flexor tibiotarsal joint muscles correlated with fatigue index as well as reduced isometric force (48%, 95% CI -1.86 to -0.61 N-m), and a 33% increase in fatigue index (95% CI -36.25 to 96.71 percent); the extensor muscles had no observable reductions in muscle force, with a 48% increase in fatigue index (95% CI -232.6 to 472.6 percent). Histological analysis of muscle biopsies supported a BMD phenotype in the flexor muscles of BMD pigs, with a 75% (95% CI -55.14 to -15.66 percent) decrease in large and a 43% (95% CI 17.74 to 57.38 percent) increase in small muscle fiber cross-sectional area. Dystrophin protein abundance was 28% less in flexor muscles from BMD pigs (95% CI -49.63 to 11.41 arbitrary units). Together, our model may serve as a clinically relevant model of BMD to assess safety and efficacy of therapeutics.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":577644,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8862,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1313305,"name":"Jacob Kendra","orcid":"0009-0002-9940-8497","position":1,"is_corresponding":false},{"id":1313680,"name":"Shadi Golpasandi","orcid":null,"position":2,"is_corresponding":false},{"id":1437528,"name":"M.L. Mackey","orcid":null,"position":3,"is_corresponding":false},{"id":1487463,"name":"Haley Russell","orcid":null,"position":4,"is_corresponding":false},{"id":1487464,"name":"Connor Hendrie","orcid":null,"position":5,"is_corresponding":false},{"id":1487168,"name":"Kuanting Chen","orcid":"0000-0002-8665-531X","position":6,"is_corresponding":false},{"id":463603,"name":"Zoë E Kiefer","orcid":"0000-0002-3064-2384","position":7,"is_corresponding":false},{"id":1487465,"name":"Jennifer M Yentas","orcid":null,"position":8,"is_corresponding":false},{"id":463605,"name":"Jason W. Ross","orcid":"0000-0003-4950-2258","position":9,"is_corresponding":false},{"id":364372,"name":"Joshua T. Selsby","orcid":"0000-0003-3797-7539","position":10,"is_corresponding":false},{"id":470291,"name":"Nicolaas E.P. Deutz","orcid":"0000-0001-5845-6447","position":11,"is_corresponding":false},{"id":753201,"name":"Peter P. Nghiem","orcid":"0000-0002-8796-8123","position":12,"is_corresponding":false},{"id":526756,"name":"Aaron B. Morton","orcid":"0000-0002-9790-705X","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T02:58:16.148027Z","pmid":"41278853","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}