{"doi":"10.1101/2025.10.09.25337396","title":"The impact and experience of a culturally adapted brief intervention for harmful alcohol use in an emergency care setting (PPKAY: Punguza Pombe Kwa Afya Yako): A case series","abstract":"Background: Harmful alcohol use is widespread in Tanzania, yet specialized resources to address this remain limited. This case series explores outcomes of three individuals who received a culturally-adapted brief intervention to reduce harmful alcohol use in an emergency department in Kilimanjaro, Tanzania. Methods: The PPKAY intervention is a 15-minute nurse-delivered motivational interview for adults with acute (< 24 h) injuries, with an Alcohol Use Disorder Identification Test (AUDIT) of 8 or above or self-reported drinking alcohol within 6 hours of injury. The primary outcome was participants' experience of the intervention. Secondary outcomes included number of binge drinking days in the prior month; depression, measured using the Patient Health Questionnaire-9 (PHQ-9); and alcohol-related consequences, measured by the Drinker Inventory of Consequences (DrInC). All outcomes were reported from baseline and at 3-month timepoints. Experience with the intervention was assessed with open-ended questions at a three-month post-intervention survey. Results: Participants reported fewer binge drinking days, improved self-efficacy in managing triggers, reduced alcohol-related consequences, remission of depression, and strengthened interpersonal relationships. These were corroborated by significantly lower AUDIT, PHQ-9, and DrInC scores. One participant was not able to meet his drinking reduction target, accompanied by an avoidance of discussing interpersonal consequences of alcohol. Conclusions: Our findings underscore the importance of integrated and targeted early screening and intervention in resource-limited emergency care settings. The narratives emphasize how a brief negotiational intervention can equip individuals with practical strategies to minimize harmful alcohol consumption. Further research is recommended to validate these outcomes in larger cohorts and diverse settings.","journal":"medRxiv","year":2025,"id":577827,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9404,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1487614,"name":"Anaelderrick Kimaro","orcid":null,"position":1,"is_corresponding":false},{"id":911678,"name":"Ashley J. Phillips","orcid":"0000-0002-8547-0719","position":2,"is_corresponding":false},{"id":398194,"name":"Linda Minja","orcid":"0000-0002-3627-6733","position":3,"is_corresponding":false},{"id":1487615,"name":"Msafiri Pesambili","orcid":null,"position":4,"is_corresponding":false},{"id":1487267,"name":"João Vitor Perez de Souza","orcid":"0009-0004-3243-0520","position":5,"is_corresponding":false},{"id":1469926,"name":"Alice Andongolile","orcid":null,"position":6,"is_corresponding":false},{"id":28624,"name":"João Ricardo Nickenig Vissoci","orcid":"0000-0001-7276-0402","position":7,"is_corresponding":false},{"id":341832,"name":"Blandina T. Mmbaga","orcid":"0000-0002-5550-1916","position":8,"is_corresponding":false},{"id":447225,"name":"Catherine A. Staton","orcid":"0000-0002-6468-2894","position":9,"is_corresponding":false},{"id":1086390,"name":"Kim Madundo","orcid":"0000-0003-0927-1678","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T02:58:16.148027Z","pmid":"41282920","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}