{"doi":"10.1101/2025.10.03.680413","title":"Discovering Condition-specific Cell Populations via Integrative Clustering of Single-cell Data","abstract":"We present IN tegrative CLustering Of Single cElls (INCLOSE), a novel computational method that integrates single-cell omics data and sample metadata to identify cell populations. INCLOSE analysis of CITE-seq data of acute myeloid leukemia and healthy samples uncovered cell populations exclusively found in the leukemia samples or the healthy samples. These condition-specific cell populations strongly suggested that immune suppression in tumor microenvironment plays a pivotal role in driving tumor progression.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":577359,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9432,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":785975,"name":"Vaishali Bhardwaj","orcid":"0000-0002-2880-0187","position":1,"is_corresponding":false},{"id":344756,"name":"Li Liu","orcid":"0000-0003-4002-7497","position":2,"is_corresponding":false},{"id":1066941,"name":"Rekha Mudappathi","orcid":"0000-0001-7965-0919","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-19T02:58:04.622308Z","pmid":"41278683","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}