{"doi":"10.1101/2025.10.02.679940","title":"Degeneration and Impaired Resilience of Skull Bone and Hematopoietic Bone Marrow","abstract":"Abstract Bone marrow health is central to transplantations, blood formation, and cancer progression. However, the bone marrow niche deteriorates with age, impairing haematopoietic stem cell function. Contrary to a recent report 1 suggesting skull marrow resists ageing, our multi-laboratory investigation reveals the opposite: the skull marrow is among the vulnerable sites of age-related decline. Ageing skull niches consistently show loss of mesenchymal and osteoprogenitors, suppression of angiogenic and lymphatic programs, adipocyte accumulation, vascular senescence, DNA replication stress, mitochondrial dysfunction, cellular senescence, and heightened inflammation. Proteomic profiling further highlights this vulnerability, demonstrating that vertebral niches—unlike the skull—are relatively spared from these ageing hallmarks. Together, these convergent datasets overturn the notion of skull-specific resilience and instead establish the skull marrow as a fragile, degenerating environment. These findings redefine marrow ageing and highlight the skull as a critical, clinically relevant target for sustaining blood and immune health and reducing vulnerability to haematological disease.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":555279,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9501,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1454076,"name":"Yonggang Fan","orcid":null,"position":1,"is_corresponding":false},{"id":1454077,"name":"Sanyam Jain","orcid":null,"position":2,"is_corresponding":false},{"id":1453576,"name":"Zhangfan Ding","orcid":"0000-0002-1107-8861","position":3,"is_corresponding":false},{"id":1453577,"name":"Hanyu Liu","orcid":"0000-0003-3503-2822","position":4,"is_corresponding":false},{"id":765542,"name":"Allison L Horenberg","orcid":"0000-0002-4011-5430","position":5,"is_corresponding":false},{"id":1454078,"name":"Haiyang Sun","orcid":"0000-0002-2332-4919","position":6,"is_corresponding":false},{"id":1454079,"name":"Mara Sophie Killer","orcid":null,"position":7,"is_corresponding":false},{"id":1453578,"name":"Abhishek Chandra","orcid":"0000-0002-9735-9436","position":8,"is_corresponding":false},{"id":1165273,"name":"Rinkoo Dalan","orcid":"0000-0001-9769-2696","position":9,"is_corresponding":false},{"id":403852,"name":"Manju Chandran","orcid":"0000-0001-9119-8443","position":10,"is_corresponding":false},{"id":1453579,"name":"Lynn Yap","orcid":"0000-0001-8698-2663","position":11,"is_corresponding":false},{"id":1453580,"name":"Junyu Chen","orcid":"0000-0003-1717-5782","position":12,"is_corresponding":false},{"id":1414434,"name":"Navin Kumar Verma","orcid":"0000-0002-5940-6633","position":13,"is_corresponding":false},{"id":852414,"name":"Christine Cheung","orcid":"0000-0001-7127-9107","position":14,"is_corresponding":false},{"id":266145,"name":"Makarand V. Risbud","orcid":"0000-0003-3913-0649","position":15,"is_corresponding":false},{"id":1453581,"name":"Aline Bözec","orcid":"0000-0001-8174-2118","position":16,"is_corresponding":false},{"id":844138,"name":"Kristijan Ramadan","orcid":"0000-0001-5522-021X","position":17,"is_corresponding":false},{"id":1073529,"name":"Martine Cohen‐Solal","orcid":"0000-0002-8582-8258","position":18,"is_corresponding":false},{"id":362359,"name":"Warren L. Grayson","orcid":"0000-0001-6099-6469","position":19,"is_corresponding":false},{"id":1453582,"name":"Saravana K. Ramasamy","orcid":"0000-0003-2658-2945","position":20,"is_corresponding":false},{"id":1360982,"name":"Anjali P. Kusumbe","orcid":"0000-0002-1911-5495","position":21,"is_corresponding":false},{"id":1453575,"name":"Yang� Yang","orcid":"0000-0003-1222-1209","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T02:54:59.329539Z","pmid":"41256358","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}