{"doi":"10.1101/2025.10.01.679819","title":"The <i>Drosophila</i> PDGF/VEGF signaling pathway regulates host immunometabolism in response to parasitoid infection","abstract":"SUMMARY Mounting an immune response requires energy, but how that energy is reallocated at the organismal level remains poorly understood. In Drosophila melanogaster , infection by a parasitoid wasp triggers a systemic metabolic switch known as immunometabolism which is characterized by a shift in metabolic activity and the redistribution of resources away from organismal development and toward the production of a cellular immune response. We identify the PDGF/VEGF (PVF) signaling pathway as a key initiator of this immunometabolic switch. Genetic manipulation of PVF signaling alters infection outcomes, modulates systemic metabolite profiles, and reveals a direct trade-off between immune function and development. Our findings establish the Drosophila- parasitoid wasp system as a genetically tractable model for understanding the molecular basis of immunometabolism.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":576699,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9546,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1450557,"name":"Abraham Y. Kpirikai","orcid":null,"position":1,"is_corresponding":false},{"id":121395,"name":"Jun Yang","orcid":null,"position":2,"is_corresponding":false},{"id":1485932,"name":"Riitvek Baddireddi","orcid":null,"position":3,"is_corresponding":false},{"id":1485933,"name":"Najeeb Marun","orcid":null,"position":4,"is_corresponding":false},{"id":830291,"name":"Nicholas M. Bretz","orcid":"0000-0003-4481-7381","position":5,"is_corresponding":false},{"id":1485934,"name":"Helen Gosnell","orcid":null,"position":6,"is_corresponding":false},{"id":1485935,"name":"Humayl Malik","orcid":null,"position":7,"is_corresponding":false},{"id":31012,"name":"David A. Hendrix","orcid":"0000-0002-7285-1977","position":8,"is_corresponding":false},{"id":426025,"name":"Nathan T. Mortimer","orcid":"0000-0003-3787-9445","position":9,"is_corresponding":false},{"id":675431,"name":"Ashley L. Waring","orcid":"0000-0002-4763-2502","position":0,"is_corresponding":true}],"reference_count":88,"raw_metadata":null,"created_at":"2026-07-19T02:58:00.620755Z","pmid":"41256414","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}