{"doi":"10.1101/2025.09.16.25335909","title":"Testing the effects of a text message intervention on depression and distress among Latino dementia caregivers: a randomized controlled trial protocol","abstract":"Background: Latino caregivers have poor mental health and access to caregiver support services. Here, we describe the protocol for a randomized controlled trial (RCT) to evaluate the effect of a text message intervention on depression and distress among informal Latino dementia caregivers. We will also assess mechanisms of action. Methods: We are enrolling 288 Latino dementia informal caregivers 18 or older into a parallel group RCT. Participants randomized to the intervention group receive a remote, asynchronous, bilingual, bi-directional, six-month texting program focused on dementia education, skill-building and community resources. The control group enters a 7-month waitlist after which they are offered the same intervention as the intervention group. Randomization is stratified by each of the four recruitment sites at a 1:1 ratio. Outcomes (e.g., caregiver depressive symptomatology, distress) are measured via surveys at baseline, 3, 6 and 7 months. Conclusions: This RCT addresse two priority areas: eliminating dementia disparities and optimizing caregiver support. Findings have the potential to make clinical and policy-relevant contributions by providing appropriate caregiver support to Latinos in a highly scalable way. Trial registration: ClinicalTrials.gov #NCT06728436. University of Kansas Medical Center STUDY00150585.","journal":"medRxiv","year":2025,"id":575236,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7903,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT06728436"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1301815,"name":"Mariana Ramirez-Mantilla","orcid":"0000-0002-2545-1057","position":1,"is_corresponding":false},{"id":1139180,"name":"Henry Moore","orcid":"0000-0002-4398-5001","position":2,"is_corresponding":false},{"id":1142164,"name":"Idaly Vélez-Uribe","orcid":"0000-0001-8260-4630","position":3,"is_corresponding":false},{"id":1282950,"name":"Vanessa Sepúlveda‐Rivera","orcid":null,"position":4,"is_corresponding":false},{"id":1483545,"name":"Rachel Ruiz","orcid":null,"position":5,"is_corresponding":false},{"id":899927,"name":"Mónica Fracachán-Cabrera","orcid":"0000-0001-9419-101X","position":6,"is_corresponding":false},{"id":1483546,"name":"Yesenia Herrera","orcid":null,"position":7,"is_corresponding":false},{"id":1104073,"name":"Christina Baker","orcid":"0000-0002-6391-0314","position":8,"is_corresponding":false},{"id":1483547,"name":"Antonio Miras-Neira","orcid":null,"position":9,"is_corresponding":false},{"id":1483548,"name":"Becky Bothwell","orcid":null,"position":10,"is_corresponding":false},{"id":414762,"name":"Heidi Anderson","orcid":null,"position":11,"is_corresponding":false},{"id":1260817,"name":"Tina Lewandowski","orcid":null,"position":12,"is_corresponding":false},{"id":324041,"name":"Francisco J. Díaz","orcid":"0000-0003-4090-228X","position":13,"is_corresponding":false},{"id":741242,"name":"K. Allen Greiner","orcid":"0000-0001-9883-4203","position":14,"is_corresponding":false},{"id":441664,"name":"Kristine Williams","orcid":"0000-0003-1312-788X","position":15,"is_corresponding":false},{"id":441662,"name":"Eric D. Vidoni","orcid":"0000-0001-5181-7131","position":16,"is_corresponding":false},{"id":324043,"name":"Edward F. Ellerbeck","orcid":"0000-0002-7774-2729","position":17,"is_corresponding":false},{"id":68016,"name":"Jeffrey M. Burns","orcid":"0000-0001-7609-8954","position":18,"is_corresponding":false},{"id":324039,"name":"Jaime Perales‐Puchalt","orcid":"0000-0003-1013-7847","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:57:48.486077Z","pmid":"41001476","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}