{"doi":"10.1101/2025.09.09.675238","title":"Gut Microbiota Shifts with Lifetime Duration of Oral Contraception Use","abstract":"To investigate the effects of lifetime duration of oral contraceptive (OC) use, we reanalyzed publicly available 16S rRNA sequencing data from fecal samples of OC users and non-users collected at different timepoints in the menstrual cycle. We profiled the microbial composition of subjects and identified 32 significantly differentially abundant Amplicon Sequence Variants (padj<0.05) with increasing lifetime use duration including 16 ASVs belonging to class Clostidia that decreased with longer OC use. Some Clostridia species are known to recycle estrogen; lifetime duration of OC exposure could thus influence women's health through gut microbiome composition and hormone regulation.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":574539,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9483,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1481865,"name":"Sayumi York","orcid":"0009-0008-3264-2143","position":1,"is_corresponding":false},{"id":1405341,"name":"Rosa Alcazar","orcid":"0000-0003-3623-4151","position":2,"is_corresponding":false},{"id":1481864,"name":"G K Paul","orcid":"0009-0002-9916-2327","position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:57:40.686992Z","pmid":"40964280","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}