{"doi":"10.1101/2025.09.01.673389","title":"An Inflammatory and Quiescent HSC Subpopulation Expands with Age in Humans","abstract":"Aging of the blood system impacts systemic health and can be traced to hematopoietic stem cells (HSCs). Despite multiple reports on human HSC aging, a unified map detailing their molecular age-related changes is lacking. We developed a consensus map of gene expression in HSCs by integrating seven single-cell datasets. This map revealed previously unappreciated heterogeneity within the HSC population. It also links inflammatory pathway activation (TNF/NFκB, AP-1) and quiescence within a single gene expression program. This program dominates an inflammatory HSC subpopulation that increases with age, highlighting a potential target for further experimental studies and anti-aging interventions.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":558983,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9168,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":499383,"name":"Dylan Kotliar","orcid":"0000-0002-7968-645X","position":1,"is_corresponding":false},{"id":983364,"name":"Michelle Curtis","orcid":"0000-0002-6843-4839","position":2,"is_corresponding":false},{"id":931957,"name":"Jonathan Good","orcid":"0000-0002-4086-5709","position":3,"is_corresponding":false},{"id":502798,"name":"Chen Weng","orcid":"0009-0003-4351-3340","position":4,"is_corresponding":false},{"id":1460211,"name":"Shawn David","orcid":null,"position":5,"is_corresponding":false},{"id":35259,"name":"Soumya Raychaudhuri","orcid":"0000-0002-1901-8265","position":6,"is_corresponding":false},{"id":1218619,"name":"Antonia Kreso","orcid":"0000-0003-0632-958X","position":7,"is_corresponding":false},{"id":302104,"name":"Jennifer J. Trowbridge","orcid":"0000-0002-7636-9504","position":8,"is_corresponding":false},{"id":17323,"name":"Vijay G. Sankaran","orcid":"0000-0003-0044-443X","position":9,"is_corresponding":false},{"id":68690,"name":"Peter van Galen","orcid":"0000-0002-0735-1570","position":10,"is_corresponding":false},{"id":1376048,"name":"Ksenia R. Safina","orcid":"0000-0002-5126-9953","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:55:30.312295Z","pmid":"40949975","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}