{"doi":"10.1101/2025.08.28.672961","title":"Automated analysis of <i>C. elegans</i> behavior by <i>LabGym</i> : an open-source, AI-powered platform","abstract":"The genetic tractability, well-mapped circuitry, and diverse behavioral repertoire of the nematode C. elegans make it an ideal model for physiological and behavioral studies. A wide range of methods has been developed for analyzing C. elegans behaviors, evolving with advances in technology such as videography and computer-assisted analysis. Here, we introduce LabGym-an open-source, artificial intelligence (AI)-based platform we recently developed-to the C. elegans research community. We trained deep learning models in LabGym capable of automatically categorizing and quantifying multiple user-defined parameters of worm locomotion behavior in multi-worm videos with high accuracy. Furthermore, we demonstrated their efficacy in quantifying locomotion changes in aging worms. Our work offers a cost-effective, user-accessible approach to behavioral analysis in C. elegans.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":574186,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9521,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1481625,"name":"Hongjiang Liu","orcid":"0000-0001-5373-8875","position":1,"is_corresponding":false},{"id":401404,"name":"Zhaoyu Li","orcid":"0000-0002-5222-6832","position":2,"is_corresponding":false},{"id":418353,"name":"X.Z. Shawn Xu","orcid":"0000-0001-7102-5035","position":3,"is_corresponding":false},{"id":129538,"name":"Bing Ye","orcid":"0000-0002-8828-4065","position":4,"is_corresponding":false},{"id":326576,"name":"Yujia Hu","orcid":"0000-0002-9792-5258","position":5,"is_corresponding":false},{"id":418350,"name":"Elizabeth A. Ronan","orcid":"0000-0001-7400-5718","position":6,"is_corresponding":false},{"id":1481624,"name":"L. Amanda Xu","orcid":"0009-0006-4557-6822","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T02:57:40.686992Z","pmid":"40950071","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}