{"doi":"10.1101/2025.07.28.667259","title":"CryoSift - An accessible and automated CNN-driven tool for cryo-EM 2D class selection","abstract":"Single-particle cryo-electron microscopy (cryo-EM) has become an essential tool in structural biology. However, automating repetitive tasks remains an ongoing challenge in cryo-EM dataset processing. Here, we present a platform-independent convolutional neural network (CNN) tool for assessing the quality of 2D averages to enable automatic selection of suitable particles for high-resolution reconstructions, termed CryoSift. We integrate CryoSift into a fully automated processing pipeline using the existing cryosparc-tools library. Our integrated and customizable 2D assessment workflow enables high-throughput processing that accommodates experienced to novice cryo-EM users.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":556613,"datarank":0.1795212208871153,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.014729377586898837,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.014729377586898837,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":2,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9524,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1455835,"name":"Austin Calza","orcid":"0009-0007-6348-3985","position":1,"is_corresponding":false},{"id":1456295,"name":"Keenan Hom","orcid":null,"position":2,"is_corresponding":false},{"id":1446444,"name":"Puneeth Damodar","orcid":"0009-0000-3250-2337","position":3,"is_corresponding":false},{"id":1257158,"name":"Ruizhi Peng","orcid":"0000-0001-6057-8961","position":4,"is_corresponding":false},{"id":1174003,"name":"Nebojša Bogdanović","orcid":"0000-0002-6811-2848","position":5,"is_corresponding":false},{"id":287919,"name":"Gabriel C. Lander","orcid":"0000-0003-4921-1135","position":6,"is_corresponding":false},{"id":308881,"name":"Scott M. Stagg","orcid":"0000-0001-8855-4152","position":7,"is_corresponding":false},{"id":297932,"name":"Michael A. Cianfrocco","orcid":"0000-0002-2067-4999","position":8,"is_corresponding":false},{"id":1446447,"name":"Jan-Hannes Schäfer","orcid":"0000-0001-8163-1629","position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:55:08.896385Z","pmid":"40766614","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}