{"doi":"10.1101/2025.07.28.667221","title":"Pentilludin reduces rat amphetamine and remifentail self-administration with good pharmacologic and toxicologic profiles","abstract":"Abstract Pentilludin is a novel, potent (690 nM) irreversible inhibitor of actions of the receptor type protein tyrosine phosphatase D (PTPRD). Pentilludin displays no in vitro activities in Ames or micronucleus tests, at hERG channels or at targets for currently-licensed drugs. Rats treated with pentilludin doses up to 100 mg/kg/day for two weeks have not been found to display behavioral, hematologic or serum chemistry abnormalities. Treatment with 20 mg/kg sc pentilludin prior to every other M-W-F self-administration session substantially reduces self-administration of amphetamine and more modestly reduces self-administration of remifentanil. Pentilludin provides a novel means for reducing self-administration of psychostimulant and, modestly, opiate drugs in ways that could enhance abstinence in humans.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":558668,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9565,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1459489,"name":"Balaji Kannan","orcid":"0009-0007-8541-5166","position":1,"is_corresponding":false},{"id":296694,"name":"Joungil Choi","orcid":null,"position":2,"is_corresponding":false},{"id":1459880,"name":"I. S. Henderson","orcid":null,"position":3,"is_corresponding":false},{"id":1459881,"name":"B. Gregory","orcid":null,"position":4,"is_corresponding":false},{"id":1459882,"name":"Jared Solon","orcid":null,"position":5,"is_corresponding":false},{"id":802500,"name":"Corinne Wells","orcid":null,"position":6,"is_corresponding":false},{"id":310255,"name":"Edward D. Levin","orcid":"0000-0002-5060-9602","position":7,"is_corresponding":false},{"id":924988,"name":"George R. Uhl","orcid":"0000-0002-5632-2426","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-19T02:55:30.312295Z","pmid":"40766574","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}