{"doi":"10.1101/2025.07.25.666806","title":"Antibodies targeting HSV glycoprotein B require effector functions to protect neonatal mice","abstract":"Abstract Glycoprotein B (gB) serves as the viral fusion protein for herpes simplex virus (HSV), mediating fusion between viral and host membranes resulting in infection. As such, gB represents a potentially critical target for the host immune system with high potential relevance for vaccine design. Here we investigated the mechanisms of protection for a panel of gB-specific monoclonal antibodies (mAb) in a mouse model of neonatal HSV (nHSV) infection. Viral neutralization contributed, but Fc effector functions were critical for mAb-mediated protection against nHSV mortality, depending on dose. Moreover, AAV-mediated in vivo expression of a gB-specific mAb in mice provided transgenerational protection against HSV-1 and HSV-2 mortality in their offspring. These findings demonstrate that antibodies targeting gB can serve as potent therapeutics and that they require diverse functional profiles to afford optimal protection, informing vaccine design.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":558607,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9639,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1459443,"name":"Lesle M. Jiménez","orcid":null,"position":1,"is_corresponding":false},{"id":294728,"name":"Iara M. Backes","orcid":"0000-0003-4389-6356","position":2,"is_corresponding":false},{"id":414786,"name":"Evelyn M. Turnbaugh","orcid":null,"position":3,"is_corresponding":false},{"id":904037,"name":"Callaghan R. Garland","orcid":"0000-0002-9745-8135","position":4,"is_corresponding":false},{"id":331515,"name":"Scott W. MacDonald","orcid":"0000-0002-0110-4026","position":5,"is_corresponding":false},{"id":108262,"name":"Alejandro B. Balazs","orcid":"0000-0002-1767-3944","position":6,"is_corresponding":false},{"id":294733,"name":"David A. Leib","orcid":"0000-0001-5539-8480","position":7,"is_corresponding":false},{"id":291270,"name":"Margaret E. Ackerman","orcid":"0000-0002-4253-3476","position":8,"is_corresponding":false},{"id":106726,"name":"Matthew D. Slein","orcid":"0000-0001-8288-787X","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T02:55:25.969263Z","pmid":"40766354","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}