{"doi":"10.1101/2025.06.23.661165","title":"MAPseq2: a sensitive barcoded connectomics method","abstract":"The barcoded connectomics tool MAPseq enables highly multiplexed projection mapping of individual neurons by translating neuroanatomy into a format solvable by DNA sequencing. Here we present MAPseq2, a user-friendly protocol with up to ~10-fold increased sensitivity compared to the current state of the art and ~10-fold decreased cost. As MAPseq workflows are used across a range of barcoded connectomics methods, including BARseq, BRICseq, and ConnectID, all improvements in MAPseq2 directly transfer to these technologies.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":555628,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9511,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1453885,"name":"Hongyi Qi","orcid":"0000-0003-0564-3892","position":1,"is_corresponding":false},{"id":1454402,"name":"Craig Washington","orcid":null,"position":2,"is_corresponding":false},{"id":1453886,"name":"Xiao Liang","orcid":"0000-0001-8789-6732","position":3,"is_corresponding":false},{"id":267317,"name":"Justus M. Kebschull","orcid":"0000-0002-4851-0267","position":4,"is_corresponding":false},{"id":1354370,"name":"Hyopil Kim","orcid":"0000-0001-9159-8682","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T02:54:59.329539Z","pmid":"41982338","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}