{"doi":"10.1101/2025.04.29.651323","title":"Exercise training remodels inter-organ endocrine networks","abstract":"Exercise induces organism-wide molecular adaptations, partly mediated by humoral factors released in response to acute and chronic physical activity. However, the extent and specificity of endocrine effects from training-induced secreted factors remain unclear. Here, we applied systems genetics approaches to quantify inter-organ endocrine networks using multi-tissue transcriptomics and proteomics data collected from endurance-trained rats in The Molecular Transducers of Physical Activity Consortium (MoTrPAC). Eight weeks of endurance training significantly altered both the magnitude and specificity of endocrine effects across multiple origin-target tissue pairs. Subcutaneous white adipose tissue emerged as a key endocrine regulator impacted by training, while extracellular matrix-derived factors were identified as globally regulated secretory features in trained vs sedentary animals. Notably, secretory Wnt signaling factors were identified as key mediators of exercise-induced endocrine adaptations in multiple tissues. Our systems genetics framework provides an unprecedented atlas of inter-organ communication significantly remodeled by endurance exercise, serving as a valuable resource for novel exerkine discovery.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":565349,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8973,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":277049,"name":"Andrea L. Hevener","orcid":"0000-0003-1508-4377","position":1,"is_corresponding":false},{"id":37000,"name":"Laurie J. Goodyear","orcid":"0000-0002-6299-2928","position":2,"is_corresponding":false},{"id":317187,"name":"Sue C. Bodine","orcid":"0000-0002-5742-9145","position":3,"is_corresponding":false},{"id":291924,"name":"Karyn A. Esser","orcid":"0000-0002-5791-1441","position":4,"is_corresponding":false},{"id":236691,"name":"Marcus Seldin","orcid":"0000-0001-8026-4759","position":5,"is_corresponding":false},{"id":235346,"name":"Lauren M. Sparks","orcid":"0000-0002-8724-6016","position":6,"is_corresponding":false},{"id":246581,"name":"Cheehoon Ahn","orcid":"0000-0003-4140-125X","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T02:56:28.709936Z","pmid":"40654889","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}