{"doi":"10.1101/2025.04.27.650870","title":"MPI-Guided Photothermal Therapy of Prostate Cancer using Stem Cell Delivery of Magnetotheranostic Nanoflowers","abstract":"Abstract Intratumoral nanoparticle (NP) injection is a commonly used for local hyperthermia. A limitation of this delivery route is the limited NP dispersion and retainment within the tumor, with undesired leakage leading to off-target toxicity. By exploiting their inherent tumor tropism, we have used human mesenchymal stem cells (hMSCs) as delivery vehicles for magnetic theranostic gold-iron oxide nanoflowers (GIONF) to improve their overall intratumoral distribution and retention. GIONF-loaded hMSCs exhibited excellent heating properties for laser photothermal therapy and high tracer performance for visualization and quantification by magnetic particle imaging (MPI). In contrast to naked GIONF, GIONF-hMSCs remained within the prostate tumors one week post-injection, with MPI-guided PTT completely ablating tumors without recurrence.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":557725,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9498,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1051395,"name":"Ana Rosu","orcid":null,"position":1,"is_corresponding":false},{"id":788933,"name":"Shreyas Kuddannaya","orcid":"0000-0001-9248-1355","position":2,"is_corresponding":false},{"id":1382788,"name":"Gautier Laurent","orcid":"0000-0002-8544-1379","position":3,"is_corresponding":false},{"id":1382789,"name":"Rana Bazzi","orcid":"0000-0001-7274-6694","position":4,"is_corresponding":false},{"id":1382787,"name":"Stéphane Roux","orcid":"0000-0002-5198-1916","position":5,"is_corresponding":false},{"id":1458218,"name":"Ali Shakeri-Zadeh","orcid":null,"position":6,"is_corresponding":false},{"id":356059,"name":"Jeff W. M. Bulte","orcid":"0000-0003-1202-1610","position":7,"is_corresponding":false},{"id":1050828,"name":"Behnaz Ghaemi","orcid":"0000-0003-2220-0428","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:55:21.727661Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}