{"doi":"10.1101/2025.04.16.649087","title":"Bat power-metabolic profiling of the Egyptian fruit bat <i>Rousettus aegyptiacus</i> reveals distinctive cardiac adaptations","abstract":"Aim: The present study aimed to elucidate which pathways contribute to cardiometabolic adaptation in Egyptian fruit bats. Methods: computational modelling using the genome-scale mammalian network CardioNet. Main Findings: Our analyses revealed that bat hearts exhibit a distinct metabolic profile characterised by depleted glycogen reserves and increased reliance on lipid oxidation to meet energy demands. Notably, bat hearts displayed elevated fluxes in oxidative phosphorylation, β-oxidation of long-chain fatty acids, and the Krebs cycle, alongside reduced amino acid catabolism. These findings suggest that bats have evolved unique metabolic strategies to support the high-energy demands of flight, maintaining cardiac function without succumbing to pathological remodelling. Conclusions: This study provides the first comprehensive insight into the metabolic adaptations in the cardiac tissue of a bat species, contributing to our understanding of how these mammals endure extreme physiological stresses. Integrating metabolomics with computational modelling offers a powerful approach to studying metabolic adaptations in non-model species, potentially informing therapeutic strategies for human cardiac conditions.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":557590,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9541,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1457737,"name":"Fenn Cullen","orcid":null,"position":1,"is_corresponding":false},{"id":1457437,"name":"Rosie Drinkwater","orcid":"0000-0001-6892-1664","position":2,"is_corresponding":false},{"id":1280517,"name":"Kyoungmin Kim","orcid":"0000-0001-5063-0869","position":3,"is_corresponding":false},{"id":1457438,"name":"Megan Young","orcid":"0009-0006-2178-3755","position":4,"is_corresponding":false},{"id":439739,"name":"Stephen J. Rossiter","orcid":"0000-0002-3881-4515","position":5,"is_corresponding":false},{"id":293949,"name":"Dunja Aksentijević","orcid":"0000-0002-8480-6727","position":6,"is_corresponding":false},{"id":293950,"name":"Anja Karlstaedt","orcid":"0000-0001-5689-3571","position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:55:17.435961Z","pmid":"41292968","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}