{"doi":"10.1101/2025.04.11.648385","title":"Gut Microbe-Derived <i>N</i> -Acyl Serinol Lipids Shape Host Postprandial Metabolic Homeostasis","abstract":"Abstract Although strong evidence links the gut microbiome to metabolic disease, the mechanisms linking microbiota to hormonal and metabolic responses to food are not well understood. After a meal, gut bacteria produce a wide array of small molecule, protein, and lipid metabolites originating from bacterial sources. Annotating physiological function to select gut microbe-derived metabolites is critical to understanding diet-microbe-host interactions, and to developing microbiome-inspired therapies to improve human health. Here, we have investigated the role of a poorly annotated class of gut microbiome-derived lipids called N -acyl amides in postprandial metabolic physiology. Here we show both bacterial overproduction and provision of exogenous N -acyl amides reorganize host hormone-driven metabolic transition after a meal. Moreover, N -acyl amides exert broad effects on the meal- and circadian-related reorganization of gene expression, metabolic hormones, and gut microbiome composition. Collectively, these results demonstrate that microbiota-derived N -acyl amides play a physiologic role in postprandial metabolic homeostasis in the host.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":564658,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.951,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":637974,"name":"K. Mahen","orcid":"0000-0002-3739-6972","position":1,"is_corresponding":false},{"id":323666,"name":"William J. Massey","orcid":"0000-0002-2087-6048","position":2,"is_corresponding":false},{"id":493466,"name":"Venkateshwari Varadharajan","orcid":"0000-0002-4557-9840","position":3,"is_corresponding":false},{"id":474989,"name":"Amy Burrows","orcid":"0000-0002-3988-5673","position":4,"is_corresponding":false},{"id":753433,"name":"Anthony Horak","orcid":"0009-0009-2024-3679","position":5,"is_corresponding":false},{"id":787164,"name":"Marko Mrdjen","orcid":"0000-0003-3000-0266","position":6,"is_corresponding":false},{"id":1467137,"name":"Nour Mouannes","orcid":null,"position":7,"is_corresponding":false},{"id":576913,"name":"Danny Orabi","orcid":"0000-0003-0009-8581","position":8,"is_corresponding":false},{"id":490845,"name":"Lucas J. Osborn","orcid":"0000-0003-0077-9192","position":9,"is_corresponding":false},{"id":991793,"name":"Treg Grubb","orcid":"0000-0002-3388-758X","position":10,"is_corresponding":false},{"id":1467139,"name":"Rachel Hohe","orcid":null,"position":11,"is_corresponding":false},{"id":854584,"name":"Rakhee Banerjee","orcid":"0000-0002-2299-7177","position":12,"is_corresponding":false},{"id":1217487,"name":"Vinayak Uppin","orcid":"0000-0002-0338-1983","position":13,"is_corresponding":false},{"id":1467141,"name":"Dev Laungani","orcid":null,"position":14,"is_corresponding":false},{"id":430645,"name":"Grace E Hamilton","orcid":"0000-0002-0522-0702","position":15,"is_corresponding":false},{"id":794696,"name":"Xiayan Ye","orcid":null,"position":16,"is_corresponding":false},{"id":263517,"name":"Naseer Sangwan","orcid":"0000-0002-2407-769X","position":17,"is_corresponding":false},{"id":570710,"name":"Mohammed Dwidar","orcid":"0000-0003-1366-0393","position":18,"is_corresponding":false},{"id":297911,"name":"Adeline M. Hajjar","orcid":"0000-0002-4838-8070","position":19,"is_corresponding":false},{"id":256163,"name":"Belinda Willard","orcid":"0000-0001-6884-6369","position":20,"is_corresponding":false},{"id":1467940,"name":"Michael Wade Martin","orcid":"0000-0003-1127-3058","position":21,"is_corresponding":false},{"id":1468337,"name":"Erik D. Guetschow","orcid":null,"position":22,"is_corresponding":false},{"id":1468338,"name":"Patrick Westcott","orcid":null,"position":23,"is_corresponding":false},{"id":261936,"name":"Zeneng Wang","orcid":"0000-0002-6455-8228","position":24,"is_corresponding":false},{"id":108895,"name":"Stanley L. Hazen","orcid":"0000-0001-7124-6639","position":25,"is_corresponding":false},{"id":261938,"name":"J. 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