{"doi":"10.1101/2025.03.12.642703","title":"A cryptochrome photoreceptor controls animal light-dependent growth and lifespan via evolutionary conserved hormonal pathways","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>\n                  Natural light is severely affected by human impact on Earth, yet little is known about the roles light receptors have outside vision and rhythmic processes. Here we show that loss-of-function of the\n                  <jats:italic>light-receptive cryptochrome</jats:italic>\n                  (\n                  <jats:italic>l-cry</jats:italic>\n                  ) in marine bristleworms significantly increases lifespan and adult size, similarly to wild-types reared in constant darkness. Quantitative transcriptomics revealed hormonal players crucial for invertebrate and vertebrate sexual development and reproduction affected in\n                  <jats:italic>l-cry</jats:italic>\n                  mutants. These include\n                  <jats:italic>nr0b1/2</jats:italic>\n                  , ortholog of\n                  <jats:italic>dax-1</jats:italic>\n                  (\n                  <jats:italic>nr0b1</jats:italic>\n                  ) and\n                  <jats:italic>shp</jats:italic>\n                  (\n                  <jats:italic>nr0b2</jats:italic>\n                  ), long considered vertebrate novelties. Depending on moon-phase,\n                  <jats:italic>nr0b1/2</jats:italic>\n                  is up- or down-regulated in\n                  <jats:italic>l-cry</jats:italic>\n                  mutants. Matching the complex regulation, loss of\n                  <jats:italic>nr0b1/2</jats:italic>\n                  function partially recapitulates\n                  <jats:italic>l-cry</jats:italic>\n                  phenotypes. Molecularly,\n                  <jats:italic>Platynereis</jats:italic>\n                  Nr0b1/2 affects steroidogenic and other endocrine pathways, nuclear receptor signaling, and transcription factor orthologs, involved in sexual developmental, reproductive, and timing processes in other organisms. Thus, our study reveals profound effects of light on adult animal life-time, likely at least in part by conserved endocrine pathways involved in sexual maturation and reproduction in annelids and vertebrates.\n                </jats:p>","journal":null,"year":null,"id":653990,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1706629,"name":"Federico Scaramuzza","orcid":"0000-0003-4360-3883","position":1,"is_corresponding":false},{"id":1706630,"name":"Aida Ćorić","orcid":"0009-0008-6767-5949","position":2,"is_corresponding":false},{"id":1706632,"name":"Lukas Orel","orcid":"0000-0001-6999-5833","position":3,"is_corresponding":false},{"id":634560,"name":"Kristin Tessmar‐Raible","orcid":"0000-0002-8038-1741","position":4,"is_corresponding":false},{"id":634544,"name":"Gabriele Andreatta","orcid":"0000-0001-8857-7282","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A cryptochrome photoreceptor controls animal light-dependent growth and lifespan via evolutionary conserved hormonal pathways","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>\n                  Natural light is severely affected by human impact on Earth, yet little is known about the roles light receptors have outside vision and rhythmic processes. Here we show that loss-of-function of the\n                  <jats:italic>light-receptive cryptochrome</jats:italic>\n                  (\n                  <jats:italic>l-cry</jats:italic>\n                  ) in marine bristleworms significantly increases lifespan and adult size, similarly to wild-types reared in constant darkness. Quantitative transcriptomics revealed hormonal players crucial for invertebrate and vertebrate sexual development and reproduction affected in\n                  <jats:italic>l-cry</jats:italic>\n                  mutants. These include\n                  <jats:italic>nr0b1/2</jats:italic>\n                  , ortholog of\n                  <jats:italic>dax-1</jats:italic>\n                  (\n                  <jats:italic>nr0b1</jats:italic>\n                  ) and\n                  <jats:italic>shp</jats:italic>\n                  (\n                  <jats:italic>nr0b2</jats:italic>\n                  ), long considered vertebrate novelties. Depending on moon-phase,\n                  <jats:italic>nr0b1/2</jats:italic>\n                  is up- or down-regulated in\n                  <jats:italic>l-cry</jats:italic>\n                  mutants. Matching the complex regulation, loss of\n                  <jats:italic>nr0b1/2</jats:italic>\n                  function partially recapitulates\n                  <jats:italic>l-cry</jats:italic>\n                  phenotypes. Molecularly,\n                  <jats:italic>Platynereis</jats:italic>\n                  Nr0b1/2 affects steroidogenic and other endocrine pathways, nuclear receptor signaling, and transcription factor orthologs, involved in sexual developmental, reproductive, and timing processes in other organisms. Thus, our study reveals profound effects of light on adult animal life-time, likely at least in part by conserved endocrine pathways involved in sexual maturation and reproduction in annelids and vertebrates.\n                </jats:p>","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":null,"pmcid":null,"openalex_id":"https://openalex.org/W4408430170","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2025,"count":1}],"oa_status":"green","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.biorxiv.org/content/biorxiv/early/2025/03/14/2025.03.12.642703.full.pdf","host_type":"repository"},{"url":"https://www.biorxiv.org/content/biorxiv/early/2025/03/14/2025.03.12.642703.full.pdf","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.1101/2025.03.12.642703","host_type":"publisher"},{"url":"https://doi.org/10.1101/2025.03.12.642703","host_type":"repository"}],"fields_of_study":["Circadian rhythm and melatonin","Spaceflight effects on biology","Photoreceptor and optogenetics research"],"mesh_terms":[],"keywords":["Cryptochrome","Biology","Conserved sequence","Blue light","Hormone","Cell biology","Evolutionary biology","Genetics","Endocrinology","Circadian clock","Gene","Base sequence","Physics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T02:37:52.708169Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}