{"doi":"10.1101/2025.03.11.25323773","title":"Factors associated with age at tau pathology onset and time from tau onset to dementia","abstract":"Abstract INTRODUCTION Elevated tau is temporally proximal to dementia onset but less is known about factors influencing T+ onset age and time to dementia following T+ in Alzheimer’s disease. We used sampled iterative localized approximation (SILA) estimated T+ onset age (ETOA) to investigate factors associated with T+ age and time from T+ to dementia onset in ADNI. METHODS Using SILA-estimated A+ and T+ onset ages derived from 18 F-Flortaucipir, 18 F-Florbetapir, and 18 F-Florbetaben PET and Cox proportional hazards and accelerated failure time models, we analyzed APOE , sex, amyloid burden, age, educational attainment, and literacy associations with ETOA and time from T+ to dementia. RESULTS Higher amyloid, APOE -ε4, lower education, and lower literacy associated with younger ETOA. Older ETOA and higher amyloid associated with shorter time from T+ to dementia. DISCUSSION This work highlights the prognostic value of ETOA and the need to better characterize factors contributing to ETOA and dementia onset in AD.","journal":"medRxiv","year":2025,"id":556086,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9182,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1310418,"name":"Jordan P Teague","orcid":"0000-0001-6688-6949","position":1,"is_corresponding":false},{"id":289692,"name":"Karly Alex Cody","orcid":"0000-0001-5996-2560","position":2,"is_corresponding":false},{"id":265268,"name":"Yuetiva Deming","orcid":null,"position":3,"is_corresponding":false},{"id":1310806,"name":"Elena Ruiz De Chavez","orcid":null,"position":4,"is_corresponding":false},{"id":1376537,"name":"Jacob Morse","orcid":null,"position":5,"is_corresponding":false},{"id":289693,"name":"Nathaniel A. Chin","orcid":"0000-0001-8008-9356","position":6,"is_corresponding":false},{"id":261840,"name":"Corinne D. Engelman","orcid":"0000-0003-4750-5607","position":7,"is_corresponding":false},{"id":395992,"name":"Richard J. Chappell","orcid":"0000-0002-3891-0881","position":8,"is_corresponding":false},{"id":289687,"name":"Rebecca L. Koscik","orcid":"0000-0003-0025-744X","position":9,"is_corresponding":false},{"id":500811,"name":"Carey E. Gleason","orcid":"0000-0001-6210-4671","position":10,"is_corresponding":false},{"id":289690,"name":"Lindsay R. Clark","orcid":"0000-0003-4837-7627","position":11,"is_corresponding":false},{"id":493819,"name":"Megan Zuelsdorff","orcid":"0000-0002-9632-475X","position":12,"is_corresponding":false},{"id":289688,"name":"Tobey J. Betthauser","orcid":"0000-0001-8856-1352","position":13,"is_corresponding":false},{"id":229339,"name":"Alzheimer’s Disease Neuroimaging Initiative","orcid":null,"position":14,"is_corresponding":false},{"id":860137,"name":"Margo B. Heston","orcid":"0000-0002-0980-2275","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-19T02:55:03.976486Z","pmid":"40162285","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}