{"doi":"10.1101/2025.02.25.25322882","title":"CD4 T cell counts are inversely correlated with anti-cluster A antibodies in antiretroviral therapy-treated PLWH","abstract":"Summary While antiretroviral therapy efficiently suppresses viral replication, inflammation and immune dysfunction persist in some people living with HIV-1 (PLWH). Soluble gp120 (sgp120) has been detected in PLWH plasma and its presence is linked to immune dysfunction. It was reported that sgp120 binding to CD4 on uninfected bystander CD4 + T cells sensitizes them to antibody-dependent cellular-cytotoxicity (ADCC) mediated by non-neutralizing antibodies present in PLWH plasma. Using three independent PLWH cohorts, we observed that non-neutralizing anti-cluster A antibodies are negatively associated with CD4 + T cell counts. Anti-CD4BS antibodies blocked the coating of uninfected bystander cells by sgp120, thereby preventing their elimination by ADCC. Supporting a protective role of anti-CD4BS antibodies, PLWH having these antibodies didn’t show a negative association between CD4 T cell counts and anti-cluster A. Our results reveal that anti-cluster A antibodies are associated with immune dysfunction in PLWH and anti-CD4BS antibodies might have a beneficial impact in these individuals.","journal":"medRxiv","year":2025,"id":562567,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9579,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":241566,"name":"Jonathan Richard","orcid":"0000-0002-9015-9589","position":1,"is_corresponding":false},{"id":1388881,"name":"Tommaso Clemente","orcid":"0000-0001-6548-3427","position":2,"is_corresponding":false},{"id":621586,"name":"Catherine Bourassa","orcid":"0000-0003-1805-8860","position":3,"is_corresponding":false},{"id":335146,"name":"William D. Tolbert","orcid":"0000-0001-7549-9596","position":4,"is_corresponding":false},{"id":546420,"name":"Suneetha Gottumukkala","orcid":null,"position":5,"is_corresponding":false},{"id":1388189,"name":"Marc-Messier Peet","orcid":null,"position":6,"is_corresponding":false},{"id":243836,"name":"Halima Medjahed","orcid":null,"position":7,"is_corresponding":false},{"id":335148,"name":"Marzena Pazgier","orcid":"0000-0003-0594-5057","position":8,"is_corresponding":false},{"id":398183,"name":"Frank Maldarelli","orcid":"0000-0002-3062-5250","position":9,"is_corresponding":false},{"id":364602,"name":"Antonella Castagna","orcid":"0000-0002-8338-9714","position":10,"is_corresponding":false},{"id":619015,"name":"Madéleine Durand","orcid":"0000-0002-9459-9549","position":11,"is_corresponding":false},{"id":241588,"name":"Andrés Finzi","orcid":"0000-0002-4992-5288","position":12,"is_corresponding":false},{"id":241571,"name":"Mehdi Benlarbi","orcid":"0000-0001-9966-3784","position":0,"is_corresponding":true}],"reference_count":89,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:56:05.550545Z","pmid":"40061344","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}