{"doi":"10.1101/2025.01.24.634706","title":"Alpha-Synuclein co-pathology in Alzheimer’s Disease drives tau accumulation","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>The molecular basis for accelerated cognitive decline seen in Alzheimer’s Disease (AD) cases presenting with cortical alpha-Synuclein (α-Syn) co-pathology is not well understood. We show that such co-pathology brains express higher levels of microtubule-associated protein tau and that increasing α-Syn expression is sufficient to drive tau accumulation. 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Our results reveal a hitherto unknown link between the pathogenesis of AD and Parkinson’s Disease whereby tau and α-Syn synergistically drive dementia-related pathology.</jats:p>","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21097893","pmcid":null,"openalex_id":"https://openalex.org/W4406865914","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"green","license":"cc-by-nc","oa_locations":[{"url":"https://www.biorxiv.org/content/biorxiv/early/2025/01/27/2025.01.24.634706.full.pdf","host_type":"repository"},{"url":"https://www.biorxiv.org/content/biorxiv/early/2025/01/27/2025.01.24.634706.full.pdf","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.1101/2025.01.24.634706","host_type":"publisher"},{"url":"https://doi.org/10.1101/2025.01.24.634706","host_type":"repository"}],"fields_of_study":["Parkinson's Disease Mechanisms and Treatments","Alzheimer's disease research and treatments","Neurological disorders and treatments"],"mesh_terms":[],"keywords":["Alpha-synuclein","Tau pathology","Disease","Parkinson's disease","Pathology","Medicine","Neuroscience","Alzheimer's disease","Psychology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-01T12:32:47.403415Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}