{"doi":"10.1101/2025.01.22.634271","title":"17β-Estradiol Counteracts Pathological Microtubule Remodeling To Enhance Cardiac Function","abstract":"Abstract The female-predominate sex hormone 17β-estradiol exerts cardioprotective effects via multiple mechanisms. Available data demonstrate 17β-estradiol modulates microtubule dynamics in vitro , but its effects on pathogenic microtubule remodeling in pressure-overloaded cardiomyocytes are unexplored. Here, we show 17β-estradiol directly blunts microtubule polymerization in vitro , counteracts endothelin-mediated microtubule remodeling in iPSC-cardiomyocytes, and mitigates microtubule stabilization in pulmonary artery banded right ventricular cardiomyocytes. 17β-estradiol treatment blunts cardiomyocyte and nuclear hypertrophy, restores t-tubule architecture, and prevents mislocalization of connexin-43 in RV cardiomyocytes of pulmonary artery banded rats. These cellular phenotypes are paired with significant improvements in RV function. Thus, we propose 17β-estradiol exerts cardioprotective effects via direct modulation of microtubules in addition to its well ascribed signaling functions.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":560828,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9474,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":938605,"name":"Neal Vogel","orcid":null,"position":1,"is_corresponding":false},{"id":1001192,"name":"Jenna B. Mendelson","orcid":"0000-0002-8229-385X","position":2,"is_corresponding":false},{"id":937940,"name":"Lynn M. Hartweck","orcid":"0000-0002-7926-3342","position":3,"is_corresponding":false},{"id":660270,"name":"John P. Carney","orcid":"0000-0002-2090-7764","position":4,"is_corresponding":false},{"id":1161684,"name":"Minwoo Kim","orcid":"0000-0002-7840-1416","position":5,"is_corresponding":false},{"id":523860,"name":"Melissa K. Gardner","orcid":"0000-0001-5906-7363","position":6,"is_corresponding":false},{"id":394462,"name":"Sasha Z. Prisco","orcid":"0000-0002-9059-0635","position":7,"is_corresponding":false},{"id":394460,"name":"Kurt W. Prins","orcid":"0000-0002-0364-6742","position":8,"is_corresponding":false},{"id":1075448,"name":"Ryan Moon","orcid":null,"position":0,"is_corresponding":true}],"reference_count":6,"raw_metadata":null,"created_at":"2026-07-19T02:55:46.921885Z","pmid":"39896522","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}