{"doi":"10.1101/2025.01.05.631367","title":"<i>C. elegans</i>\n                  interprets dietary quality through context-dependent serotonergic modulation","abstract":"<jats:title>SUMMARY</jats:title>\n                <jats:p>\n                  Animals sense their metabolic needs to guide foraging decisions using neuronal pathways that are only partly understood. Here, we systematically investigate how foraging in the nematode\n                  <jats:italic>Caenorhabditis elegans</jats:italic>\n                  is influenced by its bacterial diet,\n                  <jats:italic>E. coli</jats:italic>\n                  . By screening\n                  <jats:italic>C. elegans</jats:italic>\n                  behavior on 3983\n                  <jats:italic>E. coli</jats:italic>\n                  knockout strains, we identified 22\n                  <jats:italic>E. coli</jats:italic>\n                  metabolic mutants that are aversive to\n                  <jats:italic>C. elegans</jats:italic>\n                  in a long-term foraging assay. These include the global metabolic regulator CRP and genes affecting cysteine synthesis, vitamin B6 synthesis, and iron uptake. Serotonin, a neurotransmitter associated with feeding in many animals, allows\n                  <jats:italic>C. elegans</jats:italic>\n                  to distinguish wild-type\n                  <jats:italic>E. coli</jats:italic>\n                  from these “mediocre” diets through bidirectional signaling. Serotonin produced by the ADF serotonergic neurons supports attraction to wild-type\n                  <jats:italic>E. coli</jats:italic>\n                  with the serotonin receptor genes\n                  <jats:italic>ser-4</jats:italic>\n                  and\n                  <jats:italic>ser</jats:italic>\n                  -\n                  <jats:italic>5</jats:italic>\n                  , whereas serotonin produced by the NSM serotonergic neurons differentially drives aversion to two mediocre diets through four serotonin receptor genes,\n                  <jats:italic>ser-1, ser-7, mod-1,</jats:italic>\n                  and\n                  <jats:italic>lgc-50.</jats:italic>\n                  Serotonin receptors act in multiple target neurons, including octopamine-producing neurons that suppress aversion across all diets. In addition, dopamine promotes aversion, in part by inhibiting octopaminergic neurons. These results reveal interactions between neuromodulatory circuits in the context-dependent evaluation of dietary quality.\n                </jats:p>","journal":null,"year":null,"id":612884,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":986452,"name":"Javier Marquina-Solis","orcid":"0000-0002-1943-3442","position":1,"is_corresponding":false},{"id":997403,"name":"Lishu Yue","orcid":"0009-0007-6235-0785","position":2,"is_corresponding":false},{"id":295164,"name":"Audrey Harnagel","orcid":"0000-0002-8243-9230","position":3,"is_corresponding":false},{"id":1578272,"name":"Yarden Greenfeld","orcid":null,"position":4,"is_corresponding":false},{"id":688920,"name":"Cornelia I. Bargmann","orcid":"0000-0002-8484-0618","position":5,"is_corresponding":false},{"id":706828,"name":"Likui Feng","orcid":"0000-0003-4601-4224","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-08-02T05:24:42.801467Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}