{"doi":"10.1101/2025.01.02.24319706","title":"Emergence and Rising Prevalence of Artemisinin Partial Resistance Marker Kelch13 P441L in a Low Malaria Transmission Setting in Southern Zambia","abstract":"Abstract Increasing artemisinin partial resistance (ArtR) due to mutations in the gene encoding Kelch13 ( Pfk13 ) protein in eastern Africa is of urgent concern, and mutations, such as Pfk13 P441L, continue to emerge. We used an amplicon deep-sequencing panel to estimate the prevalence of ArtR Pfk13 mutations in samples collected between 2018 and 2023 in southern Zambia. Pfk13 P441L was present in 30 of 501 samples (6%), and prevalence increased over time (0% to 7.2%). Further studies of the P441L mutation are needed to document its geographical origin, distribution and impact on treatment outcomes.","journal":"medRxiv","year":2025,"id":554647,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.958,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1329243,"name":"Jacob M. Sadler","orcid":null,"position":1,"is_corresponding":false},{"id":353653,"name":"Alfred Simkin","orcid":"0000-0001-9408-0053","position":2,"is_corresponding":false},{"id":1061170,"name":"Michael Musonda","orcid":null,"position":3,"is_corresponding":false},{"id":407220,"name":"Ben Katowa","orcid":"0000-0002-8935-9196","position":4,"is_corresponding":false},{"id":981390,"name":"Japhet Matoba","orcid":"0000-0001-6021-659X","position":5,"is_corresponding":false},{"id":371978,"name":"Jessica L. Schue","orcid":"0000-0002-5188-5692","position":6,"is_corresponding":false},{"id":408669,"name":"Edgar Simulundu","orcid":"0000-0001-9423-0816","position":7,"is_corresponding":false},{"id":242456,"name":"Jeffrey A. Bailey","orcid":"0000-0002-6899-8204","position":8,"is_corresponding":false},{"id":270628,"name":"William J. Moss","orcid":"0000-0001-6579-3513","position":9,"is_corresponding":false},{"id":270632,"name":"Jonathan J. Juliano","orcid":"0000-0002-0591-0850","position":10,"is_corresponding":false},{"id":341338,"name":"Abebe A. Fola","orcid":"0000-0001-5392-2859","position":11,"is_corresponding":false},{"id":1316669,"name":"A. Martin","orcid":"0000-0003-0068-6519","position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":null,"created_at":"2026-07-19T02:54:54.542303Z","pmid":"39802768","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}