{"doi":"10.1101/2024.12.30.629739","title":"Immune cell single-cell RNA sequencing analyses link an age-associated T cell subset to symptomatic benign prostatic hyperplasia","abstract":"Abstract Benign prostatic hyperplasia (BPH) is among the most common age-associated diseases in men; however, the contribution of age-related changes in immune cells to BPH is not clear. The current study determined that an age-associated CD8 + T cell subset (Taa) with high Granzyme K ( GZMK hi ) and low Granzyme B ( GZMB low ) gene expression infiltrate aged human prostates and positively correlate with International Prostate Symptom Score (IPSS). A velocity analysis indicated that CD8 + T cell differentiation is altered in large BPH prostates compared to small age-matched prostates, favoring Taa accumulation. In vitro granzyme K treatment of human BPH patient-derived large prostate fibroblasts increased secretion of pro-inflammatory senescence-associated secretory phenotype (SASP)-associated cytokines. These data suggest that granzyme K-mediated stimulation of prostate stromal fibroblast SASP cytokine and chemokine production promotes prostate immune cell recruitment and activation. Overall, these results connect symptomatic BPH with immune aging.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":487617,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9624,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":338751,"name":"Nadia A. Lanman","orcid":"0000-0002-1819-7070","position":1,"is_corresponding":false},{"id":308176,"name":"Renee E. Vickman","orcid":"0000-0002-5614-9221","position":2,"is_corresponding":false},{"id":308171,"name":"Gregory M. Cresswell","orcid":"0000-0003-0616-0366","position":3,"is_corresponding":false},{"id":1025456,"name":"Harish Kothandaraman","orcid":"0000-0002-0759-4601","position":4,"is_corresponding":false},{"id":1330006,"name":"Andree K. Kolliegbo","orcid":null,"position":5,"is_corresponding":false},{"id":250408,"name":"Sebastian Juan Paez","orcid":"0000-0002-0065-1474","position":6,"is_corresponding":false},{"id":816300,"name":"Alexander P. Glaser","orcid":"0000-0003-1781-9023","position":7,"is_corresponding":false},{"id":533491,"name":"Brian T. Helfand","orcid":"0000-0002-7707-3318","position":8,"is_corresponding":false},{"id":272345,"name":"Gervaise H. Henry","orcid":"0000-0001-7772-9578","position":9,"is_corresponding":false},{"id":272360,"name":"Douglas W. Strand","orcid":"0000-0002-0746-927X","position":10,"is_corresponding":false},{"id":513644,"name":"Omar E. Franco","orcid":"0000-0002-0673-9506","position":11,"is_corresponding":false},{"id":399084,"name":"Susan E. Crawford","orcid":"0000-0003-3890-5000","position":12,"is_corresponding":false},{"id":671120,"name":"Simon W. Hayward","orcid":"0000-0002-6059-6550","position":13,"is_corresponding":false},{"id":308181,"name":"Timothy L. Ratliff","orcid":"0000-0003-4221-5416","position":14,"is_corresponding":false},{"id":308174,"name":"Meaghan M. Broman","orcid":"0000-0001-5473-1616","position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":null,"created_at":"2026-07-19T02:08:10.215754Z","pmid":"39803459","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}