{"doi":"10.1101/2024.12.16.628794","title":"BACH2-driven tissue resident memory programs promote HIV-1 persistence","abstract":"SUMMARY Transcription repressor BACH2 redirects short-lived terminally differentiated effector into long-lived memory cells. We postulate that BACH2-mediated long-lived memory programs promote HIV-1 persistence in gut CD4+ T cells. We coupled single-cell DOGMA-seq and TREK-seq to capture chromatin accessibility, transcriptome, surface proteins, T cell receptor, HIV-1 DNA and HIV-1 RNA in 100,744 gut T cells from ten aviremic HIV-1+ individuals and five HIV-1– donors. BACH2 was the leading transcription factor that shaped gut tissue resident memory T cells (TRMs) into long-lived memory with restrained interferon-induced effector function. We found that HIV-1-infected cells were enriched in TRMs (80.8%). HIV-1-infected cells had increased BACH2 transcription factor accessibility, TRM (CD49a, CD69, CD103) and survival ( IL7R ) gene expression, and Th17 polarization (RORC, CCR6 ). In vitro gut CD4+ T cell infection revealed preferential infection and persistence of HIV-1 in CCR6+ TRMs. Overall, we found BACH2-driven TRM program promotes HIV-1 persistence and BACH2 as a new therapeutic target.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":485808,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9511,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1329360,"name":"Haocong Katherine","orcid":null,"position":1,"is_corresponding":false},{"id":1329361,"name":"Michelle E. Wong","orcid":null,"position":2,"is_corresponding":false},{"id":487431,"name":"Emmanouil Papasavvas","orcid":null,"position":3,"is_corresponding":false},{"id":231799,"name":"Liza Konnikova","orcid":"0000-0003-4804-5497","position":4,"is_corresponding":false},{"id":58750,"name":"Pablo Tebas","orcid":"0000-0001-5345-7942","position":5,"is_corresponding":false},{"id":1329362,"name":"Ricardo Morgenstern","orcid":null,"position":6,"is_corresponding":false},{"id":251284,"name":"Luis J. Montaner","orcid":"0000-0001-5799-6759","position":7,"is_corresponding":false},{"id":69486,"name":"Ya‐Chi Ho","orcid":"0000-0002-7046-0147","position":8,"is_corresponding":false},{"id":1024497,"name":"Yulong Wei","orcid":"0000-0003-1218-2086","position":0,"is_corresponding":true}],"reference_count":83,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:07:52.536246Z","pmid":"39763845","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}