{"doi":"10.1101/2024.11.19.624383","title":"Long-lasting, subtype-specific regulation of somatostatin interneurons during sensory learning","abstract":"Abstract Somatostatin (SST)-expressing inhibitory neurons are a major class of neocortical γ-amino butyric acid (GABA) neurons, where morphological, electrophysiological, and transcriptomic analyses indicate more than a dozen different subtypes. However, whether this diversity is related to specific roles in cortical computations and plasticity remains unclear. Here we identify learning-dependent, subtype-specific plasticity in layer 2/3 SST neurons of the mouse somatosensory cortex. Martinotti-type, SST neurons expressing calbindin-2 show a selective decrease in excitatory synaptic input and stimulus-evoked calcium responses as mice learn a stimulus-reward association. Using these insights, we develop a label-free classifier using basal activity from in vivo imaging that accurately predicts learning-associated response plasticity. Our data indicate that molecularly-defined SST neuron subtypes play specific and highly-regulated roles in sensory information processing and learning.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":486449,"datarank":0.2577510698503367,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.01633538298522163,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.01633538298522163,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9516,"is_data_producer":true,"deposit_databanks":{"Dryad":["10.5061/dryad.qbzkh18st"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":893216,"name":"Matthew B. Mosso","orcid":"0000-0002-9270-8692","position":1,"is_corresponding":false},{"id":885698,"name":"Xiaoyang Ma","orcid":"0009-0009-6395-3187","position":2,"is_corresponding":false},{"id":689294,"name":"Eunsol Park","orcid":"0000-0001-9433-4762","position":3,"is_corresponding":false},{"id":501422,"name":"Alison L. Barth","orcid":"0000-0001-7092-1356","position":4,"is_corresponding":false},{"id":501421,"name":"Mo Zhu","orcid":"0000-0002-1235-7993","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T02:08:01.404471Z","pmid":"39605654","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}