{"doi":"10.1101/2024.11.13.623481","title":"Interictal spikes during spatial working memory carry helpful or distracting representations of space and have opposing impacts on performance","abstract":"In temporal lobe epilepsy, interictal spikes (IS) - hypersynchronous bursts of network activity - occur at high rates in between seizures. We sought to understand the influence of IS on working memory by recording hippocampal local field potentials from epileptic mice while they performed a delayed alternation task. We found that IS disrupted performance when they were spatially non-restricted and occurred during running. In contrast, when IS were clustered at reward locations, animals performed well. A machine learning decoding approach revealed that IS at reward sites were larger than IS elsewhere on the maze, and could be classified as occurring at specific reward locations - suggesting they carry informative content for the memory task. Finally, a spiking model revealed that spatially clustered IS preserved hippocampal replay, while spatially dispersed IS disrupted replay by causing over-generalization. Together, these results show that IS can have opposing outcomes on memory.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":492403,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9607,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1339096,"name":"Maryam Pasdarnavab","orcid":null,"position":1,"is_corresponding":false},{"id":1339097,"name":"Laura Kueck","orcid":null,"position":2,"is_corresponding":false},{"id":1338624,"name":"Gergely Tarcsay","orcid":"0009-0008-6214-3142","position":3,"is_corresponding":false},{"id":1141436,"name":"Laura A. Ewell","orcid":"0000-0002-1638-426X","position":4,"is_corresponding":false},{"id":1003452,"name":"Justin D. Yi","orcid":"0000-0003-1566-5382","position":0,"is_corresponding":true}],"reference_count":112,"raw_metadata":null,"created_at":"2026-07-19T02:08:56.210382Z","pmid":"39605412","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}