{"doi":"10.1101/2024.10.15.618508","title":"Lifespan of male and female APP/PS1 and APP <sup>NL-F/NL-F</sup> mouse models of Alzheimer’s disease","abstract":"Abstract Alzheimer’s disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APP NL-F/NL-F ) and their shared genetic background control (C57BL/6). Survival curves support significant sex differences between within genotypes. Minimal longevity revealed increased age in male APP/PS1, and decreased age in APP NL-F/NL-F mice. Maximal longevity revealed an increased average age in males. Furthermore, median lifespan differed between sex and genotype. This study supports sexual dimorphic survival in two mouse models of AD, emphasizing the need to examine mechanisms and treatments in both sexes.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":489169,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9204,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":371882,"name":"Yimin Fang","orcid":"0000-0001-9270-5857","position":1,"is_corresponding":false},{"id":657744,"name":"Kathleen Quinn","orcid":null,"position":2,"is_corresponding":false},{"id":1179606,"name":"Tiarra Hill","orcid":null,"position":3,"is_corresponding":false},{"id":809143,"name":"Mackenzie R. Peck","orcid":"0000-0002-2611-1150","position":4,"is_corresponding":false},{"id":356147,"name":"Andrzej Bartke","orcid":"0000-0002-2569-557X","position":5,"is_corresponding":false},{"id":356149,"name":"Kevin N. Hascup","orcid":"0000-0001-6604-1874","position":6,"is_corresponding":false},{"id":356148,"name":"Erin R. Hascup","orcid":"0000-0003-1037-0809","position":7,"is_corresponding":false},{"id":813616,"name":"Hannah Roberts","orcid":"0000-0003-2110-9542","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T02:08:23.929823Z","pmid":"39464050","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}