{"doi":"10.1101/2024.10.15.618447","title":"Autonomic Neuropathy Is Associated with An Increase in Type-1 Cytokines in People Living With HIV","abstract":"Purpose: Pre-clinical studies have demonstrated direct influences of the autonomic nervous system (ANS) on the immune system. However, it remains unclear if ANS-immune connections delineated in pre-clinical studies underlie the relationship between autonomic dysregulation and chronic inflammatory diseases in patients with HIV. This study had three aims: 1.) Examine the relationship between IL-6 and the parasympathetic/vagal component of baroreflex sensitivity (BRS-V) in people with HIV; 2.) Determine if the subtype and severity of HIV-autonomic neuropathy (AN) would predict distinct immunotypes; 3.) Compare the burden of non-AIDS-related co-morbidities between immunotypes. Methods: Levels of immune biomarkers were measured in all participants using the Target 96 Inflammation Panel on the Olink proteomics platform and immunotypes were identified using unbiased, non-negative matrix factorization. Mass cytometry (CyTOF) was completed on a subset of participants with and without autonomic neuropathy (N = 10). Results: Reduced BRS-V predicted higher levels of IL-6 (p=0.002). A pro-inflammatory immunotype defined by elevations in type 1 cytokines (IL-6, IL-17) and increased numbers of CD8+ T-cells was associated with autonomic neuropathy characterized by deficits in sympathetic nervous system activity (aOR=4.7, p=0.017). This pro-inflammatory immunotype was older with a greater burden of co-morbidities. Conclusion: Deficits in the parasympathetic/cardiovagal and the sympathetic nervous system are associated with inflammation and disease burden in people living with HIV. Future longitudinal research is needed to examine causality.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":504791,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9635,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1339443,"name":"Mitali Mehta","orcid":null,"position":1,"is_corresponding":false},{"id":1278940,"name":"Maya Campbell","orcid":"0000-0003-3760-8741","position":2,"is_corresponding":false},{"id":1339444,"name":"Niyati Neupane","orcid":null,"position":3,"is_corresponding":false},{"id":1339445,"name":"Gabriela Cedillo","orcid":null,"position":4,"is_corresponding":false},{"id":271342,"name":"Gina Lee","orcid":"0000-0002-8120-9169","position":5,"is_corresponding":false},{"id":1339446,"name":"Kaitlyn Coyle","orcid":null,"position":6,"is_corresponding":false},{"id":1339447,"name":"Jingman Qi","orcid":null,"position":7,"is_corresponding":false},{"id":305849,"name":"Zhihong Chen","orcid":"0000-0001-7403-7015","position":8,"is_corresponding":false},{"id":1296336,"name":"Mary Catherine George","orcid":"0000-0001-6886-9704","position":9,"is_corresponding":false},{"id":710509,"name":"Jessica Robinson‐Papp","orcid":"0000-0001-9397-8873","position":10,"is_corresponding":false},{"id":917241,"name":"Bridget R. Mueller","orcid":"0000-0003-4554-3343","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T02:10:39.578471Z","pmid":"39464041","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}