{"doi":"10.1101/2024.09.27.615294","title":"Charting cortical-layer specific area boundaries using Gibbs’ ringing attenuated T1w/T2w-FLAIR myelin MRI","abstract":"Cortical areas have traditionally been defined by their distinctive layer cyto- and/or myelo- architecture using postmortem histology. Recent studies have delineated many areas by measuring overall cortical myelin content and its spatial gradients using the T1w/T2w ratio MRI in living primates, including humans. While T1w/T2w studies of areal transitions might benefit from using the layer profile of this myelin-related contrast, a significant confound is Gibbs' ringing artefact, which produces signal fluctuations resembling cortical layers. Here, we address these issues with a novel approach using cortical layer thickness-adjusted T1w/T2w-FLAIR imaging, which effectively cancels out Gibbs' ringing artefacts while enhancing intra-cortical myelin contrast. Whole-brain MRI measures were mapped onto twelve equivolumetric layers, and layer-specific sharp myeloarchitectonic transitions were identified using spatial gradients resulting in a putative 182 area/subarea partition of the macaque cerebral cortex. The myelin maps exhibit notably high homology with those in humans, suggesting cortical myelin shares a similar developmental program across species. Comparison with histological Gallyas myelin stains explains over 80% of the variance in the laminar T1w/T2w-FLAIR profiles, substantiating the validity of the method. Altogether, our approach provides a novel, noninvasive means for precision mapping layer myeloarchitecture in the primate cerebral cortex, advancing the pioneering work of classical neuroanatomists.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":484586,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9485,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":690557,"name":"Akiko Uematsu","orcid":"0000-0001-6123-4247","position":1,"is_corresponding":false},{"id":663767,"name":"Takuro Ikeda","orcid":"0000-0003-1079-8725","position":2,"is_corresponding":false},{"id":277824,"name":"Takayuki Ose","orcid":"0000-0002-5672-1013","position":3,"is_corresponding":false},{"id":632671,"name":"Yujie Hou","orcid":"0000-0002-1447-8246","position":4,"is_corresponding":false},{"id":265230,"name":"Loïc Magrou","orcid":null,"position":5,"is_corresponding":false},{"id":1326756,"name":"Ikko Kimura","orcid":"0000-0002-1893-6937","position":6,"is_corresponding":false},{"id":277826,"name":"Masahiro Ohno","orcid":"0009-0007-4880-1105","position":7,"is_corresponding":false},{"id":277827,"name":"Katsutoshi Murata","orcid":"0000-0003-0615-7116","position":8,"is_corresponding":false},{"id":633621,"name":"Tim Coalson","orcid":null,"position":9,"is_corresponding":false},{"id":263064,"name":"Henry Kennedy","orcid":"0000-0002-2796-7663","position":10,"is_corresponding":false},{"id":234075,"name":"Matthew F. Glasser","orcid":null,"position":11,"is_corresponding":false},{"id":15950,"name":"David C. Van Essen","orcid":"0000-0001-7044-4721","position":12,"is_corresponding":false},{"id":268777,"name":"Takuya Hayashi","orcid":"0000-0001-7639-0197","position":13,"is_corresponding":false},{"id":277823,"name":"Joonas A. Autio","orcid":"0000-0002-2232-9259","position":0,"is_corresponding":true}],"reference_count":121,"raw_metadata":null,"created_at":"2026-07-19T02:07:42.971417Z","pmid":"39386722","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}