{"doi":"10.1101/2024.09.26.615188","title":"TRiC/CCT Chaperonin Governs RNA Polymerase II Activity in the Nucleus to Support RNA Homeostasis","abstract":"The chaperonin TRiC/CCT is a large hetero-oligomeric ringed-structure that is essential in eukaryotes. While present in the nucleus, TRiC/CCT is typically considered to function in the cytosol where it mediates nascent polypeptide folding and the assembly/disassembly of protein complexes. Here, we investigated the nuclear role of TRiC/CCT. Inactivation of TRiC/CCT resulted in a significant increase in the production of nascent RNA leading to the accumulation of noncoding transcripts. The influence on transcription was not due to cytoplasmic TRiC/CCT-activities or other nuclear proteins as the effect was observed when TRiC/CCT was evicted from the nucleus and restricted to the cytoplasm. Rather, our data support a direct role of TRiC/CCT in regulating RNA polymerase II activity, as the chaperonin modulated nascent RNA production both in vivo and in vitro. Overall, our studies reveal a new avenue by which TRiC/CCT contributes to cell homeostasis by regulating the activity of nuclear RNA polymerase II.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":487379,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9572,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":519155,"name":"Audrey Yi Tyan Peng","orcid":"0000-0001-9668-8222","position":1,"is_corresponding":false},{"id":1331696,"name":"Anusmita Biswas","orcid":null,"position":2,"is_corresponding":false},{"id":991528,"name":"Zeno Barcutean","orcid":null,"position":3,"is_corresponding":false},{"id":666877,"name":"Daniel R. Gestaut","orcid":"0000-0003-1446-0107","position":4,"is_corresponding":false},{"id":141967,"name":"Judith Frydman","orcid":"0000-0003-2302-6943","position":5,"is_corresponding":false},{"id":11009,"name":"Kevin Struhl","orcid":"0000-0002-4181-7856","position":6,"is_corresponding":false},{"id":458829,"name":"Brian Freeman","orcid":"0000-0003-1993-8974","position":7,"is_corresponding":false},{"id":991079,"name":"Zlata Gvozdenov","orcid":"0000-0001-7898-1660","position":0,"is_corresponding":true}],"reference_count":96,"raw_metadata":null,"created_at":"2026-07-19T02:08:06.013846Z","pmid":"39386699","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}