{"doi":"10.1101/2024.09.23.614609","title":"Cadherin 16 promotes sensory gating via the endocrine corpuscles of Stannius","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>\n                  Sensory thresholds enable animals to regulate their behavioral responses to environmental threats. Despite the importance of sensory thresholds for animal behavior and human health, we do not yet have a full appreciation of the underlying molecular-genetic and circuit mechanisms. The larval zebrafish acoustic startle response provides a powerful system to identify molecular mechanisms underlying establishment of sensory thresholds and plasticity of thresholds through mechanisms like habituation. Using this system, we identify Cadherin 16 as a previously undescribed regulator of sensory gating. We demonstrate that Cadherin 16 regulates sensory thresholds via an endocrine organ, the corpuscle of Stannius (CS), which is essential in zebrafish for regulating Ca\n                  <jats:sup>2+</jats:sup>\n                  homeostasis. We further show that Cadherin 16 regulates whole-body calcium and ultimately behavior through the hormone Stanniocalcin 1L, and the IGF-regulatory metalloprotease, Papp-aa. Finally, we demonstrate the importance of the CS through ablation experiments that reveal its role in promoting normal acoustic sensory gating. Together, our results uncover a previously undescribed brain non-autonomous pathway for the regulation of behavior and establish Ca\n                  <jats:sup>2+</jats:sup>\n                  homeostasis as a critical process underlying sensory gating\n                  <jats:italic>in vivo</jats:italic>\n                  .\n                </jats:p>","journal":null,"year":null,"id":689028,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1799348,"name":"Zackary Q. Marshall","orcid":null,"position":1,"is_corresponding":false},{"id":822808,"name":"Nicholas J. Santistevan","orcid":"0000-0002-4657-6860","position":2,"is_corresponding":false},{"id":889948,"name":"Stefani Gjorcheska","orcid":"0009-0007-6835-8315","position":3,"is_corresponding":false},{"id":928069,"name":"Amanda Stenzel","orcid":null,"position":4,"is_corresponding":false},{"id":889430,"name":"Lindsey Barske","orcid":"0000-0003-1275-7978","position":5,"is_corresponding":false},{"id":462175,"name":"Jessica C. Nelson","orcid":"0000-0001-7528-4245","position":6,"is_corresponding":false},{"id":1799347,"name":"Susannah S. Schloss","orcid":"0000-0002-3784-6371","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cadherin 16 promotes sensory gating via the endocrine corpuscles of Stannius","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>\n                  Sensory thresholds enable animals to regulate their behavioral responses to environmental threats. Despite the importance of sensory thresholds for animal behavior and human health, we do not yet have a full appreciation of the underlying molecular-genetic and circuit mechanisms. The larval zebrafish acoustic startle response provides a powerful system to identify molecular mechanisms underlying establishment of sensory thresholds and plasticity of thresholds through mechanisms like habituation. Using this system, we identify Cadherin 16 as a previously undescribed regulator of sensory gating. We demonstrate that Cadherin 16 regulates sensory thresholds via an endocrine organ, the corpuscle of Stannius (CS), which is essential in zebrafish for regulating Ca\n                  <jats:sup>2+</jats:sup>\n                  homeostasis. We further show that Cadherin 16 regulates whole-body calcium and ultimately behavior through the hormone Stanniocalcin 1L, and the IGF-regulatory metalloprotease, Papp-aa. Finally, we demonstrate the importance of the CS through ablation experiments that reveal its role in promoting normal acoustic sensory gating. Together, our results uncover a previously undescribed brain non-autonomous pathway for the regulation of behavior and establish Ca\n                  <jats:sup>2+</jats:sup>\n                  homeostasis as a critical process underlying sensory gating\n                  <jats:italic>in vivo</jats:italic>\n                  .\n                </jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39386705","pmcid":null,"openalex_id":"https://openalex.org/W4402837505","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"4R00NS111736-03","title":"Understanding how post-translational palmitoylation influences in vivo molecular and circuit dynamics during learning"},{"funder_name":"NINDS NIH HHS","grant_id":"R00 NS111736","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM141742","title":null}],"total_grants":3,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"cc-by-nc-nd","oa_locations":[{"url":"http://dx.doi.org/10.1101/2024.09.23.614609","host_type":"repository"},{"url":"http://dx.doi.org/10.1101/2024.09.23.614609","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.1101/2024.09.23.614609","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39386705","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11463452","host_type":"repository"},{"url":"https://doi.org/10.1101/2024.09.23.614609","host_type":""}],"fields_of_study":["Neurobiology and Insect Physiology Research","Cellular transport and secretion","Ion Channels and Receptors"],"mesh_terms":[],"keywords":["Gating","Cadherin","Endocrine system","Sensory system","Neuroscience","Chemistry","Endocrinology","Biology","Hormone","Cell","Biochemistry","Article","acoustic startle","calcium homeostasis","cdh16","corpuscles of Stannius","habituation","pappaa","sensorimotor gating","stc1l","zebrafish"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-19T21:37:01.288236Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}