{"doi":"10.1101/2024.09.19.613907","title":"Arterial spin labelling perfusion MRI analysis for the Human Connectome Project Lifespan Ageing and Development studies","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>The Human Connectome Project Lifespan studies cover the Development (5-21) and Aging (36-100+) phases of life. Arterial spin labelling (ASL) was included in the imaging protocol, resulting in one of the largest datasets collected to-date of high spatial resolution multiple delay ASL covering 3,000 subjects. The HCP-ASL minimal processing pipeline was developed specifically for this dataset to pre-process the image data and produce perfusion estimates in both volumetric and surface template space. Applied to the whole dataset, the outputs of the pipeline revealed significant and expected differences in perfusion between the Development and Ageing cohorts. Visual inspection of the group average surface maps showed that cortical perfusion often followed cortical areal boundaries, suggesting differential regulation of cerebral perfusion within brain areas at rest. Group average maps of arterial transit time also showed differential transit times in core and watershed areas of the cerebral cortex, which are useful for interpreting haemodynamics of functional MRI images. The pre-processed dataset will provide a valuable resource for understanding haemodynamics across the human lifespan.</jats:p>","journal":null,"year":null,"id":625949,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":29.7,"corpus_rank":8997,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":737751,"name":"Flora A. Kennedy McConnell","orcid":"0000-0002-5149-1511","position":1,"is_corresponding":false},{"id":1619052,"name":"Jack Toner","orcid":null,"position":2,"is_corresponding":false},{"id":1619053,"name":"Martin S. Craig","orcid":null,"position":3,"is_corresponding":false},{"id":1069685,"name":"Davide Carone","orcid":"0000-0002-1646-6089","position":4,"is_corresponding":false},{"id":420909,"name":"Xiufeng Li","orcid":"0000-0002-0764-4613","position":5,"is_corresponding":false},{"id":852577,"name":"Yuriko Suzuki","orcid":"0000-0002-4851-7872","position":6,"is_corresponding":false},{"id":277831,"name":"Timothy S. Coalson","orcid":"0000-0002-2105-7896","position":7,"is_corresponding":false},{"id":459160,"name":"Michael P. Harms","orcid":"0000-0001-7945-036X","position":8,"is_corresponding":false},{"id":234075,"name":"Matthew F. Glasser","orcid":null,"position":9,"is_corresponding":false},{"id":762343,"name":"Michael A. Chappell","orcid":"0000-0003-1802-4214","position":10,"is_corresponding":false},{"id":807950,"name":"Thomas Kirk","orcid":"0000-0002-3458-2104","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Arterial spin labelling perfusion MRI analysis for the Human Connectome Project Lifespan Ageing and Development studies","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>The Human Connectome Project Lifespan studies cover the Development (5-21) and Aging (36-100+) phases of life. Arterial spin labelling (ASL) was included in the imaging protocol, resulting in one of the largest datasets collected to-date of high spatial resolution multiple delay ASL covering 3,000 subjects. The HCP-ASL minimal processing pipeline was developed specifically for this dataset to pre-process the image data and produce perfusion estimates in both volumetric and surface template space. Applied to the whole dataset, the outputs of the pipeline revealed significant and expected differences in perfusion between the Development and Ageing cohorts. Visual inspection of the group average surface maps showed that cortical perfusion often followed cortical areal boundaries, suggesting differential regulation of cerebral perfusion within brain areas at rest. Group average maps of arterial transit time also showed differential transit times in core and watershed areas of the cerebral cortex, which are useful for interpreting haemodynamics of functional MRI images. The pre-processed dataset will provide a valuable resource for understanding haemodynamics across the human lifespan.</jats:p>","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19910364","pmcid":null,"openalex_id":"https://openalex.org/W4402794808","authors":[],"funders":[{"funder_name":"UK Research and Innovation","grant_id":"EP/P012361/1","title":"Controlling structure induced variations in non-invasive perfusion MRI of neurodegeneration"},{"funder_name":"National Institutes of Health","grant_id":"3U01AG052564-02S2","title":"Mapping the Human Connectome During Typical Aging"},{"funder_name":"National Institutes of Health","grant_id":"1R24MH122820-01","title":"Connectome Coordination Facility II"},{"funder_name":"National Institutes of Health","grant_id":"5U19AG073585-02","title":"VULNERABILITY AND RESILIENCY IN THE AGING ADULT BRAIN CONNECTOME (AABC)"},{"funder_name":"National Institutes of Health","grant_id":"5R24MH108315-04","title":"Connectome Coordination Facility"},{"funder_name":"UK Research and Innovation","grant_id":"EP/P012361/2","title":"Controlling structure induced variations in non-invasive perfusion MRI of neurodegeneration"},{"funder_name":"Wellcome Trust","grant_id":"203139","title":"Wellcome Centre for Integrative Neuroimaging"},{"funder_name":"National Institutes of Health","grant_id":"3U01MH109589-02S1","title":"Mapping the Human Connectome During Typical Development"}],"total_grants":8,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2025,"count":2}],"oa_status":"green","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1101/2024.09.19.613907","host_type":"repository"},{"url":"https://doi.org/10.1101/2024.09.19.613907","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.1101/2024.09.19.613907","host_type":"publisher"},{"url":"https://doi.org/10.1162/imag_a_00444","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/40084116","host_type":""},{"url":"http://dx.doi.org/10.1162/imag_a_00444","host_type":""}],"fields_of_study":["Functional Brain Connectivity Studies","Advanced MRI Techniques and Applications","Advanced Neuroimaging Techniques and Applications","05 social sciences","0501 psychology and cognitive sciences"],"mesh_terms":[],"keywords":["Arterial spin labeling","Labelling","Connectome","Perfusion","Neuroscience","Ageing","Human Connectome Project","Medicine","Psychology","Cardiology","Internal medicine","Functional connectivity","Criminology","Article"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T11:40:14.354197Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}