{"doi":"10.1101/2024.09.10.612361","title":"Distinct input-specific mechanisms enable presynaptic homeostatic plasticity","abstract":"ABSTRACT Synapses are endowed with the flexibility to change through experience, but must be sufficiently stable to last a lifetime. This tension is illustrated at the Drosophila neuromuscular junction (NMJ), where two motor inputs that differ in structural and functional properties co-innervate most muscles to coordinate locomotion. To stabilize NMJ activity, motor neurons augment neurotransmitter release following diminished postsynaptic glutamate receptor functionality, termed p resynaptic h omeostatic p otentiation (PHP). How these distinct inputs contribute to PHP plasticity remains enigmatic. We have used a botulinum neurotoxin to selectively silence each input and resolve their roles in PHP, demonstrating that PHP is input-specific: Chronic (genetic) PHP selectively targets the tonic MN-Ib, where active zone remodeling enhances Ca 2+ influx to promote increased glutamate release. In contrast, acute (pharmacological) PHP selectively increases vesicle pools to potentiate phasic MN-Is. Thus, distinct homeostatic modulations in active zone nanoarchitecture, vesicle pools, and Ca 2+ influx collaborate to enable input-specific PHP expression.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":488964,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9516,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":571611,"name":"Kaikai He","orcid":"0000-0003-2002-4862","position":1,"is_corresponding":false},{"id":249657,"name":"Sarah L. Perry","orcid":"0000-0003-2301-6710","position":2,"is_corresponding":false},{"id":1334343,"name":"Elizabeth Tchitchkan","orcid":null,"position":3,"is_corresponding":false},{"id":382966,"name":"Yifu Han","orcid":"0000-0002-1201-654X","position":4,"is_corresponding":false},{"id":382967,"name":"Xiling Li","orcid":"0000-0002-2727-244X","position":5,"is_corresponding":false},{"id":382968,"name":"Dion Dickman","orcid":"0000-0003-1884-284X","position":6,"is_corresponding":false},{"id":674188,"name":"Chun Chien","orcid":"0000-0003-0132-8457","position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:08:23.929823Z","pmid":"39314403","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}