{"doi":"10.1101/2024.09.03.24312664","title":"Sex differences in the trajectories of plasma biomarkers, brain atrophy, and cognitive decline relative to amyloid onset","abstract":"Abstract INTRODUCTION: The factors that influence the progression of Alzheimer's disease (AD) after individuals become amyloid-positive are poorly understood. This study examines how sex influences the longitudinal trajectories of plasma AD and neurodegenerative biomarkers in the years following a person's estimated onset of amyloid-β. METHODS: Linear mixed effects modeling investigated overall and sex-specific longitudinal trajectories of plasma biomarkers, brain volumes, and cognition relative to estimated age of amyloid onset in a cohort of 78 amyloid-positive Baltimore Longitudinal Study of Aging participants (n=45 male; follow-up time: 6.8 years [SD 3.31]). Amyloid status was ascertained with 11C-Pittsburgh compound B (PiB) PET imaging. RESULTS: After amyloid onset, men displayed steeper increases in pTau181, pTau231, and NfL compared to women. In this same period, men demonstrated steeper declines in brain volume and cognitive performance. DISCUSSION: These findings suggest that sex influences the trajectory of AD pathology, neuronal injury, and symptom progression after individuals become amyloid-positive.","journal":"medRxiv","year":2024,"id":491767,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9504,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":250664,"name":"Murat Bilgel","orcid":"0000-0001-5042-7422","position":1,"is_corresponding":false},{"id":254759,"name":"Yang An","orcid":"0000-0002-3312-7265","position":2,"is_corresponding":false},{"id":27596,"name":"Abhay Moghekar","orcid":"0000-0001-9464-1551","position":3,"is_corresponding":false},{"id":241104,"name":"Nicholas J. Ashton","orcid":"0000-0002-3579-8804","position":4,"is_corresponding":false},{"id":841866,"name":"Przemysław R. Kac","orcid":"0000-0001-5083-0924","position":5,"is_corresponding":false},{"id":241105,"name":"Thomas K. Karikari","orcid":"0000-0003-1422-4358","position":6,"is_corresponding":false},{"id":27600,"name":"Kaj Blennow","orcid":"0000-0002-1890-4193","position":7,"is_corresponding":false},{"id":27601,"name":"Henrik Zetterberg","orcid":"0000-0003-3930-4354","position":8,"is_corresponding":false},{"id":107085,"name":"Madhav Thambisetty","orcid":"0000-0002-2200-2299","position":9,"is_corresponding":false},{"id":21956,"name":"Luigi Ferrucci","orcid":"0000-0002-6273-1613","position":10,"is_corresponding":false},{"id":230044,"name":"Susan M. Resnick","orcid":"0000-0003-1115-7145","position":11,"is_corresponding":false},{"id":34922,"name":"Keenan A. Walker","orcid":"0000-0002-5989-9853","position":12,"is_corresponding":false},{"id":1209405,"name":"Cassandra M Joynes","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:08:45.247225Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}