{"doi":"10.1101/2024.08.09.606346","title":"Adaptive immunity to retroelements promotes barrier integrity","abstract":"Abstract Maintenance of tissue integrity is a requirement of host survival. This mandate is of prime importance at barrier sites that are constitutively exposed to the environment. Here, we show that exposure of the skin to non-inflammatory xenobiotics promotes tissue repair; more specifically, mild detergent exposure promotes the reactivation of defined retroelements leading to the induction of retroelement-specific CD8 + T cells. These T cell responses are Langerhans cell dependent and establish tissue residency within the skin. Upon injury, retroelement-specific CD8 + T cells significantly accelerate wound repair via IL-17A. Collectively, this work demonstrates that tonic environmental exposures and associated adaptive responses to retroelements can be coopted to preemptively set the tissue for maximal resilience to injury.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":491591,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.96,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":621633,"name":"Djalma S. Lima‐Junior","orcid":"0000-0002-2092-8047","position":1,"is_corresponding":false},{"id":80484,"name":"Verena M. Link","orcid":"0000-0002-3207-312X","position":2,"is_corresponding":false},{"id":232579,"name":"Margery Smelkinson","orcid":"0000-0001-7777-5574","position":3,"is_corresponding":false},{"id":623633,"name":"Siddharth R. Krishnamurthy","orcid":"0000-0003-1777-8292","position":4,"is_corresponding":false},{"id":265816,"name":"Liang Chi","orcid":"0000-0002-3769-4144","position":5,"is_corresponding":false},{"id":551826,"name":"Elisha Segrist","orcid":"0000-0003-4840-113X","position":6,"is_corresponding":false},{"id":342497,"name":"Taylor K. Farley","orcid":"0000-0002-9926-1475","position":7,"is_corresponding":false},{"id":1106983,"name":"Ana Teijeiro","orcid":"0000-0003-2276-7950","position":8,"is_corresponding":false},{"id":235854,"name":"Nicolas Bouladoux","orcid":"0000-0003-1593-671X","position":9,"is_corresponding":false},{"id":225267,"name":"Yasmine Belkaid","orcid":"0000-0001-9962-3571","position":10,"is_corresponding":false},{"id":295927,"name":"Alexandria Wells","orcid":"0000-0001-9799-8353","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T02:08:45.247225Z","pmid":"39149266","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}