{"doi":"10.1101/2024.08.07.607092","title":"The synaptonemal complex aligns meiotic chromosomes by wetting","abstract":"Abstract During meiosis, the parental chromosomes are drawn together to enable exchange of genetic information. Chromosomes are aligned through the assembly of a conserved interface, the synaptonemal complex, composed of a central region that forms between two parallel chromosomal backbones called axes. Here we identify the axis-central region interface in C. elegans , containing a conserved positive patch on the axis component HIM-3 and the C-terminus of the central region protein SYP-5. Crucially, the canonical ultrastructure of the synaptonemal complex is altered upon weakening this interface. We developed a thermodynamic model that recapitulates our experimental observations, indicating that the liquid-like central region can assemble by wetting the axes without active energy consumption. More broadly, our data show that condensation drives tightly regulated nuclear reorganization during sexual reproduction.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2024,"id":488815,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9506,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1333380,"name":"Alyssa A. Rodriguez","orcid":"0000-0001-8689-572X","position":1,"is_corresponding":false},{"id":847688,"name":"Yajie Gu","orcid":"0000-0002-1514-1477","position":2,"is_corresponding":false},{"id":106560,"name":"Kevin D. Corbett","orcid":"0000-0001-5854-2388","position":3,"is_corresponding":false},{"id":620537,"name":"Chiu Fan Lee","orcid":"0000-0003-4363-9050","position":4,"is_corresponding":false},{"id":302747,"name":"Ofer Rog","orcid":"0000-0001-6558-6194","position":5,"is_corresponding":false},{"id":567485,"name":"Spencer G. Gordon","orcid":"0000-0001-9787-406X","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T02:08:19.655720Z","pmid":"39149313","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}